Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon
Reference (41)
- et al.
Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined fluorescent tracer and acetylcholinesterase analysis
Brain Res. Bull.
(1982) - et al.
A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells
J. biol. Chem.
(1984) Cholinergic function and intellectual decline in Alzheimer's disease
Neuroscience
(1986)Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord
Brain Res.
(1988)- et al.
Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro
Neurosci. Lett.
(1987) - et al.
NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?
Devl Brain Res.
(1983) - et al.
Cholinergic neurons in the rat substantia nigra
Neurosci. Lett.
(1986) - et al.
Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions
Brain Res.
(1984) - et al.
Nerve growth factor increases choline acetyltransferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons
Neuroscience
(1985) - et al.
Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain
Neurosci. Lett.
(1986)
Organization and morphological characteristics of cholinergic neurons: an immunocytochemical study with a monoclonal antibody to choline acetyltransferase
Brain Res.
Cholinergic nucleus basalis neurons may influence the cortex via the thalamus
Neurosci. Lett.
Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transported Phaseolus vulgaris leucoagglutinin
Brain Res
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons
Molec. Brain Res.
Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions
Brain Res.
Nerve growth factor (NGF) in the rat CNS: absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra
Brain Res.
Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat
Brain Res.
Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions
Behav. Brain Res.
Cholinergic projections to the basolateral amygdala: a combined Evans Blue and acetylcholinesterase analysis
Brain Res. Bull.
Cholinergic systems in the rat brain—III. Projections from the pontomescencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain
Brain Res. Bull.
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2023, Cannabis Use, Neurobiology, Psychology, and TreatmentCholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions
2021, International Journal of Biochemistry and Cell BiologyEffects of chronic alcohol consumption and withdrawal on the cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei of the rat: An unbiased stereological study
2020, NeuroToxicologyCitation Excerpt :It is possible that the higher resistance of mesopontine cholinergic neurons to chronic alcohol exposure relative to their basal forebrain counterparts might be related to some particular features of these neurons. First, the mesopontine cholinergic neurons, contrary to the basal forebrain cholinergic neurons, do not express the high (trkA) and the low affinity (p75) NFG receptors (Mesulam et al., 1989; Woolf et al., 1989a; Cuello et al., 1990; Pioro and Cuello, 1990a, 1990b; Heckers et al., 1994; Sobreviela et al., 1994). Consequently, and as opposed to what happens to their basal forebrain counterparts (Knüsel and Hefti, 1988; Mesulam et al., 1989; Woolf et al., 1989a; Koliatsos et al., 1994; Sofroniew et al., 2001; Cuello et al., 2007, 2010; Niewiadomska et al., 2011), the maintenance of their phenotype is not dependent on NGF (Knüsel and Hefti, 1988; Mesulam et al., 1989; Woolf et al., 1989a), whose trophic support is known to be altered by chronic alcohol consumption (De Simone and Aloe, 1993; Walker et al., 1993; Miller et al., 2002; Miller and Mooney, 2004; Fiore et al., 2009).
Impaired hippocampal and thalamic acetylcholine release in P301L tau-transgenic mice
2019, Brain Research BulletinNeurophysiology of the pedunculopontine tegmental nucleus
2019, Neurobiology of DiseaseCitation Excerpt :A further level of complexity in the heterogeneity of PPTg neurons is that they contain the corticotropin-releasing hormone or substance P, atriopeptin and nitric oxide synthase co-localized with ACh. Only non-cholinergic PPTg neurons have been reported to express the calcium-binding D28k protein, while the cholinergic neurons of the PPTg together with those of the laterodorsal tegmental nucleus (LDTN) have been distinguished from those of the basal forebrain based on their high levels of NADPH diaphorase activity and nitric oxide synthase (Austin et al., 1995; Cote and Parent, 1992; Dawson et al., 1991; Edley and Graybiel, 1983; Geula et al., 1993; Standaert et al., 1986; Wanaka et al., 1990; Woolf et al., 1989). Finally, additional neurochemical features that have helped to localize the PPTg from surrounding basal forebrain structures are the high density of fibroblast growth factor receptors in the area in which the PPTg is located and the lack of nerve growth factor receptors in the cholinergic PPTg neurons.
The fate of the brain cholinergic neurons in neurodegenerative diseases
2017, Brain ResearchCitation Excerpt :A toxic interaction between Aβ and tau proteins is suggested by Small and Duff (2008) and is supported by the work of Pooler et al. (2015) in which an increase in tau neuronal toxicity was observed in rTgTauEC transgenic mice crossed with APP/PS1 mice. The midpontine cholinergic neurons forming the Ch5 and Ch6 nuclei do not express NGF receptors (Richardson et al., 1986; Woolf et al., 1989) and, as shown in Table 1, undergo degeneration in PD, PD with dementia, LBD, and PSP but are spared in AD, CBS and fronto-parietal dementias. As mentioned above, frontoparietal dementias, including Pick’s disease, CBS and PSP are considered tauopathies since they are characterized by fibrils and fibrillary tangle formation.