N--methyl-d-aspartate receptors mediate activation of the c-fos proto-oncogene in a model of brain injury

doi:10.1016/0306-4522(90)90081-E

Neuroscience

Volume 35, Issue 2, 1990, Pages 273-281

https://doi.org/10.1016/0306-4522(90)90081-E Get rights and content

Abstract

The proto-oncogene c-fos is rapidly and transiently induced in the CNS by a variety of stimuli. Brain injury, disruption of pia-arachnoid in a limited area, is one of the situations that leads to a dramatic increase in c-fos immunoreactivity. This increase is limited to the lesioned hemisphere. Injections of atropine (25 mg/kg, i.p.), naltrexone (5 mg/kg, i.p.), nifedipine (5 mg/kg, i.p.), and f N-(6-aminohexyl-5-chloro-1-naphthalenesulfonamide (20 mg/kg, i.p.), prior to the injury, did not affect the activation of c-fos as assessed by immunohistochemistry in adult Sprague-Dawley rats perfused 2 h after the lesion. The non-competitive N-methyl-d-aspartate antagonists ketamine (100 mg/kg, i.p.) and MK-801 {(+)-5-methyl-10, 11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate} (1 and 3 mg/kg, i.p.) markedly reduced c-fos activation. Phencyclicline (10 mg/kg, i.p.) produced a slight reduction in damage-induced fos activation.

This study suggests that c-fos activation in this particular model is N-methyl-d-aspartate receptor mediated and supports the idea that the fos proto-oncogene might play a role in plasticity and/or neurotoxic changes following brain damage.

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N--methyl-d-aspartate receptors mediate activation of the c-fos proto-oncogene in a model of brain injury

Abstract

Expl Neurol.

Neurosci. Lett.

Brain Res.

Brain Res.

Expl Neurol.

Neurosci. Lett.

Brain Res.

J. Pharmac.

Trends Neurosci.

Neurosci. Lett.

Biochim. Biophys. Acta

Brain Res.

Neurosci. Lett.

Eur. J. Pharmac.

Neuroscience

Brain. Res.

Expl Neurol.

Molec. Brain Res.

Phencyclicline interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane

The dissociative anaesthetics, ketamine and phencyclicline selectively reduce excitation of central mammalian neurons by N--methyl-d-aspartate

Br. J. Pharmac.

Sites of action of phencyclicline. III. Interactions with muscarinic receptors

Molec. Pharmac.

Systemic approaches to modifying quinolinic acid striatal lesions in rat

J. Neurosci.

Muscarinic suppression of a novel voltage-sensitive current in a vertebrate neuron

Nature

Localization of a family of muscarinic receptor mRNAs in rat brain

J. Neurosci.

Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus

Nature