Recovery from unilateral 6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin substance P1–11
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Cited by (52)
NK<inf>3</inf> receptor agonism reinstates temporal order memory in the hemiparkinsonian rat
2015, Behavioural Brain ResearchCitation Excerpt :It is worth noting that substance P (SP), which also binds to the NK3-R, may have neuroprotective properties in the 6-OHDA lesion model of PD. Chronic administration of SP decreased ipsiversive turning in rats with partial DA depletion either treated after [33] or before the lesion [35,36]. As, however, other studies reported contradictory findings [37,38], the role of NK3-R in the recovery from motor deficits requires further investigation.
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway
2011, NeuropharmacologyCitation Excerpt :It could regulate glutamate driving neurotransmission, excitotoxicity and neuronal degeneration (Barker, 1991, 1996; Severini et al., 2003). Administration of NK1 peptide could restore the dopamine level in striatum of 6-OHDA lesioned rats (Mattioli et al., 1992; Krasnova et al., 2000). Previous findings have also shown that NK1 peptide protected different in vitro models from various conditions (Calvo et al., 1996; Lallemend et al., 2003; Amadoro et al., 2007).
Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats
2009, Behavioural Brain Research