Suppression of ponto-geniculo-occipital waves by neurotoxic lesions of pontine caudo-lateral peribrachial cells

doi:10.1016/0306-4522(95)00081-S

Neuroscience

Volume 67, Issue 3, August 1995, Pages 703-712

https://doi.org/10.1016/0306-4522(95)00081-S Get rights and content

Abstract

Ponto-geniculo-occipital waves precede rapid eye movement sleep and play an important role in triggering and maintaining rapid eye movement sleep. Ponto-geniculo-occipital waves have been implicated in several important functions such as sensorimotor integration, learning, cognition, development of the visual system, visual hallucination, and startle response. Peribrachial area neurons have long been thought to play a key role in the triggering of ponto-geniculo-occipital wave. However, the exact location within the peribrachial area for triggering pontine ponto-geniculo-occipital wave has not been unequivocally demonstrated. In an attempt to address this issue, kainic acid was microinjected (1.0 μg) unilaterally into the caudo-lateral peribrachial area of four cats in order to destroy the cell bodies located in that region and thus to study the effects of their destruction upon waking-sleep states and ponto-geniculo-occipital waves. The kainic acid produced a small spherical area of nerve cell loss and/or gliosis centered on the stereotaxic coordinates of P: 4.0, L: 4.5, and H: −2.5. The maximum diameter of that spherical area of cell loss was 0.9 mm. Unilateral lesioning of the caudo-lateral peribrachial area decreased ponto-geniculo-occipital waves during rapid eye movement sleep by 85% ipsi-laterally and 15% contralaterally in the lateral geniculate body without significantly changing the amounts of time spent in wake, slow-wave sleep, and rapid eye movement sleep.

These results suggest that the caudo-lateral peribrachial area cells are critical to the genesis of ponto-geniculo-occipital waves, and provide compelling evidence that the different parts of the peribrachial area have quite different roles in the generation of discrete rapid eye movement sleep signs. We propose that caudo-lateral peribrachial cells exert an excitatory influence on rostral peribrachial cells, which then directly activate the ponto-geniculo-occipital waves that are recorded in the lateral geniculate body. Results of this study are not only important to understand the mechanisms generating ponto-genicula-occipital waves but also could be used as an experimental tool to study the functions of this wave.

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Suppression of ponto-geniculo-occipital waves by neurotoxic lesions of pontine caudo-lateral peribrachial cells

Abstract

Neuroscience

Brain Res.

Neuropharmacology

Expl Neurol.

Brain Res.

Electroenceph. Clin. Neurophysiol.

Electroenceph. Clin. Neurophysiol.

Neurosci. Lett.

Neurosci. Lett.

J. Autonom. Nerv. Syst.

Brain Res.

Brain Res.

Brain Res.

Expl Neurol.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Electroenceph. Clin. Neurophysiol.

Brain Res.

Electroenceph. Clin. Neurophysiol.

Electroenceph. Clin. Neurophysiol.

Brain Res.

Expl Neurol.

Neurosci. Biobehav. Rev.

Brain Res.

Neuroscience

Brain Res.

Brain Res.

Respiratory synchronizing function of the nucleus parabrachialis medialis: pneumotaxic mechanism

J. Neurophysiol.

Functional connections between pontine reticular formation and lateral geniculate nucleus during deep sleep

Arch. Ital. Biol.

Brain stem electrical activity during deep sleep

Arch. Ital. Biol.

Topographic organization of cardiovascular responses to electrical and glutamate microstimulation of the use of the parabrachial nucleus in the rat

J. comp. Neurol.

Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation

J. Physiol. (London)

In situ injection of kainic acid: a new method for selectively lesioning neuronal cell bodies while sparing axons of passage

J. comp. Neurol.

The function of dream sleep

Nature

Cholinergic microstimulation of the peribrachial nucleus in the cat. I. Immediate and prolonged increased in ponto-geniculo-occipital waves

Arch. Ital. Biol.