ArticleAscending afferent regulation of rat midbrain dopamine neurons
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2017, Progress in NeurobiologyCitation Excerpt :The responses recorded in the SNc were heterogeneous after DRN stimulation, inhibiting only “slowly firing” cells with a basal activity below 4 Hz (Kelland et al., 1990), and producing initial excitation on some neurons (Gervais and Rouillard, 2000). In the VTA, DA neurons could respond by excitation or inhibition (Gervais and Rouillard, 2000) while the mesoaccumbens neurons were inhibited (Kelland et al., 1993). The inhibitory response of SNc and VTA DA neurons triggered by DRN stimulation was eliminated by 5-HT depletion with para-chlorophenylalanine (pCPA) or 5,7-dihydroxytryptamine (5,7-DHT), but the percentage of DA neurons initially excited was maintained (Fibiger and Miller, 1977; Gervais and Rouillard, 2000).
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2016, Pharmacology and TherapeuticsCitation Excerpt :These inhibitory effects could involve 5-HT2CRs but the demonstration is missing. Lesion of 5-HT neurons or depletion of 5-HT does not modify DA neuron firing rate (Kelland et al., 1990, 1993; Prisco et al., 1994; Prisco & Esposito, 1995; Gervais & Rouillard, 2000; Guiard et al., 2008) although it is sometimes associated with subtle changes of the discharge profile of DA neurons (Prisco et al., 1994; Guiard et al., 2008). The tonic control exerted by 5-HT2CRs on DA neuron firing rate is consequently not clear and could be related to the nature and the selectivity of the 5-HT2C antagonists/inverse agonists used to unmask the continuous regulations (see below) or the contribution of other 5-HTRs.
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2014, NeuroscienceCitation Excerpt :Hot water applied to the tail produces responses in SNc DA neurons (Tsai et al., 1980) and noxious tail pinch produces responses in both SNc and VTA DA neurons (Mantz et al., 1989; Ungless et al., 2004). Tsai et al. (1980) initially reported that all DA neurons are inhibited, an observation which was confirmed by Ungless et al. (2004) for neurochemically identified DA neurons in the VTA, and which fits with the accounts of short-latency (<100 ms) inhibitory responses in SNc and VTA DA neurons to protracted stimulation of the sciatic nerve (Hommer and Bunney, 1980; Tsai et al., 1980; Kelland et al., 1993). However, some DA neurons are activated rather than inhibited by noxious tail pinch, foot pinch or foot shock (Mantz et al., 1989; Coizet et al., 2006), and the most recent picture that has emerged is that there may be two populations of DA neurons in the VTA of the rat – one which responds with activation and one which responds with inhibition to noxious stimuli (Brischoux et al., 2009).
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