Brief noteThe Drosophila melanogaster ribosomal S6 kinase II-encoding sequence☆
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Cited by (21)
Modelling Learning and Memory in Drosophila to Understand Intellectual Disabilities
2020, NeuroscienceCitation Excerpt :Gene transcription controlled by CREB represents an important molecular switch, controlling the transition from short-term, protein synthesis-independent memory formation to long-term, protein synthesis-dependent memory storage (DeZazzo and Tully, 1995; Martin et al., 1997; Alberini, 2009). In Drosophila, there is only one RSK gene, demonstrating the greatest homology with the human RSK2 gene (60–63% sequence identity at protein level) (Wassarman et al., 1994 and Table 1.). Interestingly, in Drosophila, RSK negatively regulates spine morphology in synaptic boutons by inhibition of ERK signaling (Fischer et al., 2009) and its full deletion leads to defects in learning (Putz et al., 2004; Neuser et al., 2008), indicating that its function in the brain is conserved across species.
The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior
2012, Journal of Biological ChemistryCitation Excerpt :N-terminal kinase activity was thought to be essential for RSK function until a recent study demonstrated an alternative role for RSK in fly eye development as a non-catalytic, scaffolding protein (15). The mammalian genome encodes four isoforms of RSK (RSK 1–4) while only a single isoform has been described for Drosophila melanogaster (dRSK or S6KII) that has ∼60% amino acid identity with RSK1 (16). Whereas there have been extensive studies of RSK structure and function using mammalian cell-based assays, detailed studies of fly S6KII functional domains have not been reported even though the kinase is known to be important for memory functions and circadian behavior (17–19).
P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons
2009, Molecular and Cellular NeuroscienceInvolvement of p90 ribosomal S6 kinase in termination of cell cycle arrest during development of Artemia-encysted embryos
2008, Journal of Biological ChemistryRole and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
1999, Molecular and Cellular Endocrinology
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On request, the authors will supply detailed experimental evidence for the conclusions presented in this Brief Note.