Research paperQuantitative evaluation of myelinated nerve fibres and hair cells in cochleae of humans with age-related high-tone hearing loss
References (36)
- et al.
Analysis of the human auditory nerve
Hear. Res.
(1989) Das alternde Ohr: Funktionelle Aspekte
HNO
(1971)- et al.
Morphological correlates of aging in the chinchilla cochlea
Hear. Res.
(1990) Überschwellige Befunde des Ton- und Sprachgehörs bei Presbyacusis
Arch. Otorhinolaryngol.
(1980)Cellular pattern and nerve supply in the human organ of Corti
Acta Otolaryngol. (Stockh.)
(1968)- et al.
An animal model for presbycusis
Laryngoscope
(1971) - et al.
Comparative study of age-related cochlear hair cell loss
Ann. Otol. Rhinol. Laryngol.
(1986) - et al.
Patterns of pure tone loss in presbycusis
Acta Otolaryngol. (Stockh.)
(1971) - et al.
A comparative study of the effect of age on the human cochlear and vestibular neuroepithelia
Acta Otolaryngol. (Stockh.)
(1987) - et al.
Age, noise and hearing loss
Ann. Otol. Rhinol. Laryngol.
(1961)
Incidence of hearing decline in the elderly
Acta Otolaryngol. (Stockh.)
Correlations of histologic observations and the acuity of hearing
Acta Otolaryngol. (Stockh.)
Age-related loss of auditory sensitivity in two mouse genotypes
Acta Otolaryngol. (Stockh.)
The anatomical locus of Presbycusis
J. Speech Hear. Disorders
Degenerative Veränderungen im alternden Innenohr mit besonderer Berücksichtigung der vasculären Veränderungen, in Flächenpräparaten der menschlichen Cochlea dargestellt
Arch. Klin. Exp. Ohr- Nasen- u. Kehlk. Heilkunde
A direct approach to cochlear anatomy and pathology in man
Arch. Otolaryngol.
Observations on the pattern of sensorineural degeneration in the human cochlea
Acta Otolaryngol. (Stockh.)
Hair cell counts in age graded series of rat cochleas
Hear. Res.
Cited by (74)
The ultrastructural study of human cochlear nerve at different ages
2022, Hearing ResearchCitation Excerpt :We have already shown that in the human fetal CN the axonal area of the neurons increases from 12 weeks to 38 weeks of gestation and that myelinated axons are first seen at 20 weeks of gestational age and thickness of the myelin sheath progressively increases (Ray et al., 2005). Other investigators have reported the loss of CN fibres and its morphological alterations with increasing age, but most of these studies have been performed in a small number of human samples (Felder and Schrott-Fischer, 1995) or in animals (Hoeffding and Feldman, 1988). Most of these studies have reported on the number of axons in the nerves.
Phoenix auditory neurons as 3R cell model for high throughput screening of neurogenic compounds
2022, Hearing ResearchCitation Excerpt :More recently, however, the focus has shifted more towards the bipolar SGNs, that wire sensory hair cells to the brainstem and perform sound processing already at the peripheral level of the inner ear. Schuknecht's model of neural hearing loss (Merchant and Nadol, 2010) is based on human temporal bone work decades earlier (Felder and Schrott-Fischer, 1995) and may be very relevant for age-related HL in humans today. Furthermore, hair cells are no longer regarded as a prerequisite for SGN survival (Zilberstein et al., 2012).
The search for noise-induced cochlear synaptopathy in humans: Mission impossible?
2019, Hearing ResearchPrimary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear
2019, NeuroscienceCitation Excerpt :There are several prior studies of primary neural degeneration, i.e. ANF loss without commensurate IHC loss, in the human literature. A study of three ears age 53–67 yrs with high-tone hearing loss and poor speech discrimination scores (70–75% in quiet) vs. two “controls” (similar ages, but with 100% speech scores), used plastic-embedded, osmium-stained wholemounts to count hair cells and then sectioned the plastic blocks to count ANF peripheral axons (Felder and Schrott-Fischer, 1995), much as we did here using virtual re-sectioning of confocal z-stacks. Despite minimal IHC loss, there was 30–40% loss of peripheral axons in the poor-performing ears.