Individual differences in hypothalamic-pituitary-adrenal activity in later life and hippocampal aging
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2011, Frontiers in NeuroendocrinologyCitation Excerpt :Chronic elevation of glucocorticoids is associated with affective, cognitive and even psychotic disorders [272]. Accumulating evidence suggests that cognitive impairments with ageing associate with elevated glucocorticoid levels in rodents and humans [168]. Indeed, maintenance of low glucocorticoid level throughout life, either via neonatal ‘programming’ of GR and MR in hippocampus which afford tighter HPA axis control, by antidepressant drugs which up-regulate GR and MR in the hippocampus and other feedback sites in adulthood to similar effect, or by adrenalectomy with low-dose glucocorticoid replacement in mid-life, prevent the emergence of cognitive deficits with age [140,166,314].