Microglial—Neuronal interactions
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Cited by (97)
The complex role of inflammation and gliotransmitters in Parkinson's disease
2023, Neurobiology of DiseaseCitation Excerpt :Microglia, CNS myeloid cells which are the self-renewing tissue resident macrophages, are heterogenous and survey the CNS parenchyma at steady state via a network of tiny processes. At rest, microglia are termed ramified, and phenotypically characterized by a small cell body, with fine processes extending outwards (Hristovska and Pascual, 2015; Lier et al., 2021; Morioka et al., 1993; Streit, 1993; Streit, 2002; Streit and Graeber, 1993). During insult or injury, microglia become active phagocytes and exhibit an activated, macrophage-like ameboid phenotype (Gopinath et al., 2020b; Shaerzadeh et al., 2020; Streit, 2002).
Dual functions of microglia in the formation and refinement of neural circuits during development
2019, International Journal of Developmental NeuroscienceCitation Excerpt :Although synaptic pruning by microglia during development was only demonstrated in this decade, a similar role of microglial “synaptic stripping” has been known in the context of neural injury for half a century (Blinzinger and Kreutzberg, 1968). After motor nerve injury, activated microglia adhere to cell bodies of injured motor neurons and enwrap them (Streit, 1993; Moran and Graeber, 2004). During this process, microglial processes invade the clefts of axosomatic synapses and disconnect presynaptic input from the surface of the injured neurons (Kreutzberg, 1993; Schiefer et al., 1999), presumably reducing their excitotoxicity (Eroglu and Barres, 2010).
Inflammation and spinal cord injury: Infiltrating leukocytes as determinants of injury and repair processes
2006, Clinical Neuroscience Research