Neuron
ArticlePolypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing
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Neural cell adhesion molecules in brain plasticity and disease
2013, Multiple Sclerosis and Related DisordersCitation Excerpt :They differ in their expression sites: NCAM-120 being found in glia, NCAM-140 in neurons and glia, and NCAM-180 in neurons (Noble et al., 1985). Other isoforms of NCAM involve a 30-base pair VAriable domain Spliced Exon (VASE) microexon insertion found in about 40–45% of all transcripts in the adult brain (Small et al., 1988) and a 37-amino acid Muscle Specific Domain (MSD) insertion between the two fibronectin III domains of NCAM found in skeletal muscle (Dickson et al., 1987). Post-translational modification also occurs in the form of a polysialic acid (PSA, a long linear homopolymer of α2,8-sialic acid) moiety on the Ig5 module and NCAM is the major, if not exclusive, carrier of this amount of negatively-charged sugar in the body.
Structure of two FREP genes that combine IgSF and fibrinogen domains, with comments on diversity of the FREP gene family in the snail Biomphalaria glabrata
2001, GeneCitation Excerpt :Although not observed from cDNA, a mini exon with appropriate type 1 splice sites was encountered within Intron 3 of FREP2. The mini exon was of interest because it raises the possibility of creating additional variability in FREPs, as has been observed in other proteins (Small et al., 1988). Incorporation of this mini exon in a transcript would elongate the ICR of FREP2 by 13 or 23 aa.
Molecular diversity in zebrafish NCAM family: Three members with different VASE usage and distinct localization
2001, Molecular and Cellular NeuroscienceThe neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system
1998, Experimental GerontologyMolecular cloning of ssd-form neural cell adhesion molecules (N-CAMs) as the major form in Xenopus heart
1998, Biochemical and Biophysical Research Communications