Neuron
In vivo release of DOPA and dopamine from genetically engineered cells grafted to the denervated rat striatum
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Gene therapy for dopamine replacement
2010, Progress in Brain ResearchCitation Excerpt :However, at least in some cases, it remained ambiguous if the decrease seen in the rotational response to apomorphine was, at least partly, due to non-specific damage of the striatal parenchyma caused by graft overgrowth (Horellou et al., 1990b). To further improve the efficacy of this approach, expression of the AADC gene was also introduced in the same cells (Horellou et al., 1990a; Kang et al., 1993; Wachtel et al., 1998). However, this appeared to have a detrimental effect on the behavioral recovery and the extracellular dopamine levels, which was documented both in vitro and in vivo.
Microdialysis in central nervous system disorders and their treatment
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2005, Brain Research ProtocolsViral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord
2004, Progress in Brain ResearchCitation Excerpt :In addition, the treatment induced enhanced sprouting of axons in the direction of the cellular source of NGF (Rosenberg et al., 1988). Because immortalized fibroblasts implanted in the CNS can give rise to tumors (Horellou et al., 1990), follow up studies used implanted primary skin fibroblasts to circumvent the risk of tumorigenesis. The fibroblasts were genetically engineered to produce NGF and proved to be beneficial in a model that assesses the regeneration of cholinergic neurons of the rat septum.