Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line

doi:10.1016/0896-6273(90)90347-I

Neuron

Volume 5, Issue 6, December 1990, Pages 875-880

https://doi.org/10.1016/0896-6273(90)90347-I Get rights and content

Abstract

In a neural cell line, the secretion of excitatory amino acids in response to a depolarizing stimulus is potentiated by the addition of serotonin. The duration of this potentiation is dependent on the strength of the stimulus. Persistent secretory potentiation induced by a strong stimulus requires the activation of both serotonin and NMDA receptors. Inhibiting the NMDA receptor during serotonin presentation prevented the induction of potentiation. The temporal characteristic of the potentiation is correlated with the elevation of cAMP levels. Serotonin exposure while inhibiting NMDA receptors results in a transient elevation of cAMP levels, whereas coactivation with NMDA and serotonin results in a persistent elevation of cAMP Thus, it is possible to obtain potentiation of secretion in a single cell either transiently or persistently. The timing of potentiated responses in this system is of the same magnitude as that in similar systems used as models for short-term and long-term memory.

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Neuron

Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line

Abstract

Eur. J. Pharmacol.

Brain Res. Rev.

Neuron

Cell

Trends Neurosci.

Trends Neurosci.

Neurosci. Lett.

Neuron

Neuron

Trends Neurosci.

Trends Neurosci.

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

Science

The tide of memory, turning

Science

Reduction of long-term potentiation in the dentate gyrus of the rat following selective depletion of monoamines

J. Physiol.

Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats

J. Physiol.

Long-term synaptic potentiation

Science