Neuron
ArticleSurvival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa
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Gene therapy in hemiparkinsonian rhesus monkeys: Long-term survival and behavioral recovery by transplantation of autologous human tyrosine hydroxylase-expressing neural stem cells
2010, CytotherapyCitation Excerpt :The insertion of therapeutic genes into the brain or into cells in vitro that are implanted into the brain is an alternative approach. Previous reports have shown that rodent models of DA depletion, in which tyrosine hydroxylase (TH), a rate-limiting enzyme in DA biosynthesis, is stably introduced into cells ex vivo are efficacious; these engineered cells can be implanted into the denervated striatum (4–6). Unfortunately, the transplanted cells are targets of disease-specific degenerative processes and immune rejection, and some cell sources experience uncontrolled replication.
Dopamine release modifies intracellular calcium levels in tyrosine hydroxylase-transfected C6 cells
2007, Brain Research BulletinGenetically engineered human neural stem cells for brain repair in neurological diseases
2007, Brain and DevelopmentEffects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival
2007, Brain ResearchCitation Excerpt :The reported negative impact of grafting on dyskinesias does not imply that neural grafting has failed to fulfil its clinical promise, but rather that it remains critical to the field of cell replacement, whether the source is embryonic, stem or other, to understand the means by which enhanced survival, and therefore enhanced and homogeneous DA fiber reinnervation, can be attained. Gene therapy for the treatment of PD has mainly been directed at the delivery of trophic factors and dopaminergic enzymes to cells of the striatum (in vivo gene therapy) (Sortwell and Kordower, 2006) or to non-neuronal cells that are subsequently grafted (ex vivo) (Bankiewicz et al., 1997; Fisher et al., 1991; Freed et al., 1990; Horellou et al., 1990; Lundberg et al., 1996; Tseng et al., 1997; Wolff et al., 1989). Very little research has investigated the feasibility of ex vivo gene delivery to mesencephalic DA neurons in an effort to increase their survival rate after grafting.
Somatic gene transfer to the brain: A tool to study the necessary and sufficient structure/function requirements for learning and memory
2019, Plasticity in the Central Nervous System: Learning and Memory