The cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil

doi:10.1016/0896-6273(91)90253-V

Neuron

Volume 6, Issue 3, March 1991, Pages 455-467

https://doi.org/10.1016/0896-6273(91)90253-V Get rights and content

Abstract

Drosophila dunce (dnc) flies are defective in learning and memory as a result of lesions in the gene that codes for a CAMP-specific phosphodiesterase (PDE). Antibodies to the dnc PDE showed that the most intensely stained regions in the adult brain were the mushroom body neuropil-areas previously implicated in learning and memory. In situ hybridization demonstrated that dnc RNA was enriched in the mushroom body perikarya. The mushroom bodies of third instar larval brains were also stained intensely by the antibody, suggesting that the dnc PDE plays an important role in these neurons throughout their development. The role of the dnc PDE in mushroom body physiology is discussed, and a circuit model describing a possible role of the mushroom bodies in mediating olfactory learning and memory is presented.

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References (39)

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Trends Neurosci.

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Cited by (0)

Neuron

ArticleThe cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil

Abstract

Dev. Biol.

Trends Neurosci.

Adv. Insect Physiol.

Neuron

Are the structural changes in adult Drosophila mushroom bodies memory traces? Studies on biochemical learning mutants

J. Neurogenet.

Searching for pattern and mutation in the Drosophila genome with a P-IacZ vector

Genes Dev.

Conditioning of leg position in normal and mutant Drosophila

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Proc. Natl. Acad. Sci. USA

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase

Isolation of the Drosophila melanogaster dunce chromosomal region and recombinational mapping of dunce sequences with restriction site polymorphisms as genetic markers

Mol. Cell. Biol.

Drosophila cyclic nucleotide phosphodiesterases

dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system

J. Cell Biol.

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

Mutations affect storage and use of memory differentially in Drosophila

Neurogenetic dissection of learning and shortterm memory in Drosophila

Annu. Rev. Neurosci.

dunce, a mutant of Drosophila deficient in learning

Three Drosophila mutations that block associative learning also affect habituation and sensitization

Localization of short-term memory in the brain of the bee, Apis mellifera

Physiol. Entomol.

Article
The cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce⁺ gene, the structural gene for cAMP phosphodiesterase

Cloning and characterization of mammalian homologs of the Drosophila dunce⁺ gene