Role of residual calcium in synaptic depression and posttetanic potentiation: Fast and slow calcium signaling in nerve terminals

doi:10.1016/0896-6273(91)90337-Y

Neuron

Volume 7, Issue 6, December 1991, Pages 915-926

https://doi.org/10.1016/0896-6273(91)90337-Y Get rights and content

Abstract

Trains of action potentials evoked rises in presynaptic Ca²⁺ concentration ([Ca²⁺]_i) at the squid giant synapse. These increases in [Ca²⁺]_i were spatially nonuniform during the trains, but rapidly equilibrated after the trains and slowly declined over hundreds of seconds. The trains also elicited synaptic depression and augmentation, both of which developed during stimulation and declined within a few seconds afterward. Microinjection of the Ca²⁺ buffer EGTA into presynaptic terminals had no effect on transmitter release or synaptic depression. However, EGTA injection effectively blocked both the persistent Ca²⁺ signals and augmentation. These results suggest that transmitter release is triggered by a large, brief, and sharply localized rise in [Ca²⁺]_i, while augmentation is produced by a smaller, slower, and more diffuse rise in [Ca²⁺]_i.

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^‡: Present address: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

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Neuron

ArticleRole of residual calcium in synaptic depression and posttetanic potentiation: Fast and slow calcium signaling in nerve terminals

Abstract

Cell Calcium

Biophys. J.

Trends Pharmacol.

J. Biol. Chem.

Biophys. J.

Trends Neurosci.

Trends Neurosci.

Neurosci. Lett.

Trends Biochem. Sci.

Neuron

Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse

J. Physiol.

Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse

J. Neurosci.

Intracellular pH changes induced by calcium influx during electrical activity in molluscan neurons

J. Gen. Physiol.

On the role of mitochondria in transmitter release from motor nerve terminals

J. Physiol.

Calcium dependence of presynaptic calcium cu rrent and post-synaptic response at the squid giant synapse

J. Physiol.

Divalent cations differentially support transmitter release at the squid giant synapse

J. Physiol.

Calcium requirements for secretion in bovine chromaffin cells

J. Physiol.

Calcium action in synaptic transmitter release

Annu. Rev. Neurosci.

Fingering the trigger for neurotransmitter secretion: studies on the calcium channels of squid giant presynaptic terminals

The kinetics of transmitter release at the frog neuromuscular junction

J. Physiol.

Depression of transmitter release at the neuromuscular junction of the frog

J. Physiol.

Facilitation of transmitter release at squid synapses

J. Gen. Physiol.

Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse

J. Physiol.

Calcium levels measured in a presynaptic neurone of Aplysia under conditions that modulate transmitter release

J. Physiol.

Statistical factors involved in neuromuscular facilitation and depression

J. Physiol.

Calcium in motor nerve terminals associated with posttetanic potentiation

J. Neurosci.

The effect of reduced calcium on quantal unit current and release at the crayfish neuromuscular junction

Pfl:lugers Arch.

The role of calcium ions in tetanic and post tetanic increase of miniature end plate potential frequency

J. Physiol.

Voltage-dependent and calcium-dependent inactivation of calcium channel current in identified snail neurones

J. Physiol.

Cytosolic Ca2+ gradients triggering unidirectional fluid secretion from exocrine pancreas

Nature

Article
Role of residual calcium in synaptic depression and posttetanic potentiation: Fast and slow calcium signaling in nerve terminals

Cytosolic Ca²⁺ gradients triggering unidirectional fluid secretion from exocrine pancreas