Neuron
ArticleEnhancement of hippocampal excitatory synaptic transmission by platelet-activating factor
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2010, Neurochemistry InternationalPlatelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region
2010, NeuroscienceCitation Excerpt :By contrast, synapsin I (Ser-603) phosphorylation was transiently increased by PAF treatment (Fig. 3), consistent with LTP-induced synapsin I phosphorylation by CaMKII in the hippocampal CA1 region (Fukunaga et al., 1993). Enhanced hippocampal synaptic transmission by PAF is mediated by its activity at presynaptic sites (Clark et al., 1992; Kato and Zorumski, 1996; Grassi et al., 1999). Taken together, increased synapsin I and GluR1 phosphorylation through CaMKII activation is likely critical for PAF-induced synaptic potentiation observed in the hippocampal CA1 region.
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