The active role of βγ in signal transduction
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Activation of β- and α2-adrenergic receptors stimulate tubulin polymerization and promote the association of Gβγ with microtubules in cultured NIH3T3 cells
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :G-protein heterotrimers are typically classified into four classes: Gs, Gi, GQ and G12-13. Typical effectors of Gα/Gβγ signaling include adenylyl cyclase, phospholipases, ion channels, and several kinases and transcription factors [6–8,18–20]. While activation of the β-adrenergic receptor leads to activation of Gαs and in turn, stimulates adenylyl cyclase and subsequent production of cAMP, activation of the α2-adrenergic receptor mediates a decrease in adenylyl cyclase activity and cAMP production through the inhibitory G protein Gαi [7].
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2006, Cellular SignallingCloning and characterization of a novel G protein β-subunit of pearl oyster (Pinctada fucata), and its interaction sites with calmodulin
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