Regeneration of hair cells in the vestibulocochlear system of birds and mammals

doi:10.1016/0959-4388(94)90051-5

Current Opinion in Neurobiology

Volume 4, Issue 4, August 1994, Pages 509-514

https://doi.org/10.1016/0959-4388(94)90051-5 Get rights and content

Under a Creative Commons license

open archive

Abstract

Regeneration of hair cells leads to a structural and functional recovery in the mature avian vestibular and auditory sensory epithelia. This regeneration replaces hair cells that have been lost as a result of noise damage, ototoxic drug poisoning, or other trauma. Recent findings suggest that it may be possible to induce a similar mechanism for repair in the vestibular and auditory epithelia of mammals, including humans.

Abbreviations

BrdU—5-bromo-2′-deoxyuridine

NM—nucleus magnocellularis

RA—retinoic acid

SEM—scanning electron microscopy

TGF—transforming growth factor