Development of hematopoietic stem cell activity in the mouse embryo

doi:10.1016/1074-7613(94)90081-7

Immunity

Volume 1, Issue 4, July 1994, Pages 291-301

https://doi.org/10.1016/1074-7613(94)90081-7 Get rights and content

Abstract

The precise time of appearance of the first hematopoietic stem cell activity in the developing mouse embryo is unknown. Recently the aorta-gonad-mesonephros region of the developing mouse embryo has been shown to possess hematopoietic colony-forming activity (CFU-S) in irradiated recipient mice. To determine whether the mouse embryo possesses definitive hematopoietic stem cell activity in the analogous AGM region and to determine the order of appearance of stem cells in the yolk sac, AGM region, and liver, we transferred these embryonic tissues into adult irradiated recipients. We report here the long-term, complete, and functional hematopoietic repopulation of primary and serial recipients with AGM-derived cells. We observe potent hematopoietic stem cell activity in the AGM region before the appearance of yolk sac and liver stem cell activity and discuss a model for the maturation of stem cell activity in mouse embryogenesis.

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^∗: Present address: Max Planck Institut fur Immunbiologie, Stübeweg 51, 79108 Freiburg, Federal Republic of Germany

^‡: Present address: Erasmus University, Department of Cell Biology and Genetics, 3000 DR Rotterdam, The Netherlands

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Immunity

ArticleDevelopment of hematopoietic stem cell activity in the mouse embryo

Abstract

Cell Differ.

Dev. Biol.

Blood

Blood

Cell

Cell

Cell

Dev. Blol.

Sem. Dev. Biol.

Adv. Genet.

Dev. Biol.

Dev. Biol.

Cell

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

Cell

Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras

J. Exp. Med.

The wall of the chick embryo aorta harbours M-CFC, G-CFC, GM-CFC and BFU-E

Development

In vitro induction of adult erythropoiesis in early mouse yolk sac

Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage

On the origin of haematopoietic stem cells in the avian embryo: an experimental approach

J. Embryol. Exp. Morphol.

Requirement for mast cell growth factor for primordial germ cell survival in culture

Nature

DNAasel hypersensitive sites 1, 2 and 3 of the human D-globin dominant control region direct position-independent expression

Nucl. Acids Res.

Structure of the murine Thy-1 gene

EMBO J.

Effects of the steel gene product on mouse primordial germ cells in culture

Nature

Para-aortic splanchnopleura from early mouse embryos contains B1 a cell progenitors

Nature

Differentiation of the mouse hepatic primordium. II. Extrinsic origin of the hematopoietic cell line

Cell Diff.

Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo

In vitro differentiation of B cells and myeloid cells from the early mouse embryo and its extraembryonic yolk sac

Exp. Hematol.

Article
Development of hematopoietic stem cell activity in the mouse embryo