Short communicationA comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide
Section snippets
Acknowledgements
We thank J. Labruyere and A. Nardi for technical assistance and John Kreitler for constructing the hyperbaric chamber. Supported in part by NIH grants AG 11355 and DA05072, FAER/ABBOTT New investigator Award (VJT), Career Development Award (NIH) DA00406 (VJT) and a NARSAD 2000 Toulmin Distinguished Investigator Award (JWO). The present work was presented in part at the annual meeting of the American Society of Anesthesiology (1998), Orlando, FL, USA.
References (20)
- et al.
Current status of ketamine anaesthesia
Lancet
(1971) - et al.
Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: potential relevance to schizophrenia?
Biol. Psychiatry
(1995) - et al.
Clinical studies of induction agents. XXXVI: Ketamine
Br. J. Anaesth.
(1970) - et al.
A study of ketamine as an obstetrical anesthetic agent
Am. J. Obstetric Gynecol.
(1972) - et al.
Sex-dependent differences in the pharmacological action and pharmacokinetics of phencyclidine in rats
Eur. J. Pharmacol.
(1984) Effect of age and sex on N-methyl-d-aspartate antagonist-induced neuronal necrosis in rats
Stroke
(1996)- et al.
Metabolic disposition of tritium labeled ketamine (Ketalar, CI-581) in normal human subjects
Clin. Res.
(1970) - et al.
Biotransformation and disposition of ketamine
Int. Anesthesiol. Clin.
(1974) - et al.
Metabolism of nitrous oxide by human and rat intestinal contents
Anesthesiology
(1980) - et al.
Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome
Science
(2000)
Cited by (112)
A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801
2021, Neurotoxicology and TeratologyCitation Excerpt :By contrast, our neuropathology study utilized female Han Wistar rats, with either intraperitoneal or intravenous routes of administration. Another comparative study, which did find lesion formation, used doses in excess of 40 mg/kg and intraperitoneal drug injection with rats (Jevtovic-Todorovic et al., 2001). Another study reported that intraperitoneal doses of 100 mg/kg in female rats were necessary to induce HSP-70 formation, a biomarker for NMDAR antagonist neurotoxicity (Tian et al., 2018).
Intranasal esketamine: From origins to future implications in treatment-resistant depression
2021, Journal of Psychiatric ResearchSex differences in response to ketamine as a rapidly acting intervention for treatment resistant depression
2019, Journal of Psychiatric ResearchCitation Excerpt :If further research supports sex differences in ketamine treatment efficacy and safety contrary to our findings, it will be important to explore how underlying mechanisms contribute to distinctions. Previous studies have suggested sex differences in ketamine metabolism (Guo et al., 2016; Jevtovic-Todorovic et al., 2001; Livingston and Waterman, 1977). Other mechanisms could relate to sex differences in the function of glutamatergic cells (Gray et al., 2015) or variables of genetic expression (Gray et al., 2015).
Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions
2018, Journal of Affective Disorders