Elsevier

Brain Research

Volume 962, Issues 1–2, 7 February 2003, Pages 226-231
Brain Research

Short communication
Different effects of phencyclidine and methamphetamine on firing activity of medial prefrontal cortex neurons in freely moving rats

https://doi.org/10.1016/S0006-8993(02)03967-7Get rights and content

Abstract

The purpose of this study was to compare the effects of systemically administered MAP with those of phencyclidine (PCP), both of which induced comparable locomotor activity, on firing activity of medial prefrontal cortex (mPFC) neurons in freely moving rats. The results show that, unlike PCP, acutely administered MAP produced little changes in firing activity of mPFC neurons.

Section snippets

Acknowledgements

This work was supported by a Grant-in-aid for Scientific Research (No. 11670958) from the Japan Society for the Promotion of Science, and by a grant from the Fukushima Society for the Promotion of Medicine to the first author. We thank Dainippon Pharmaceutical Corporation for their generous donation of PCP. We also thank Doctor Yoshiyuki Tanaka for his helpful advice, and Nobuko Anzai for her excellent technical assistance.

References (29)

  • Y. Suzuki et al.

    Acute administration of phencyclidine induces tonic activation of medial prefrontal cortex neurons in freely moving rats

    Neuroscience

    (2002)
  • P. Winn

    Schizophrenia research moves to the prefrontal cortex

    Trends Neurosci.

    (1994)
  • Y. Yonezawa et al.

    Involvement of gamma-aminobutyric acid neurotransmission in phencyclidine-induced dopamine release in the medial prefrontal cortex

    Eur. J. Pharmacol.

    (1998)
  • C.R.J. Ashby et al.

    Electrophysiological evidence for a functional interaction between 5-HT1A and 5-HT2A receptors in the rat medial prefrontal cortex: an iontophoretic study

    Synapse

    (1994)

    • Cited by (0)

    View full text
    Copyright © 2002 Elsevier Science B.V. All rights reserved.