Elsevier

Brain Research

Volume 780, Issue 2, 12 January 1998, Pages 352-355
Brain Research

Short communication
Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex

https://doi.org/10.1016/S0006-8993(97)01352-8Get rights and content

Abstract

The effects of the anti-estrogen, anion channel blocker, tamoxifen on amino acid release from the ischemic rat cerebral cortex was investigated using a cortical cup technique. Tamoxifen (20 μM in artificial cerebrospinal fluid), applied topically, inhibited the ischemia-evoked efflux of aspartate, glutamate, taurine and phosphoethanolamine. Reductions in the ischemia-evoked levels of these amino acids suggest that tamoxifen may attenuate chloride-related osmotic cell swelling and the associated regulatory volume decrease (RVD) release of amino acids.

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Acknowledgements

This work was supported by USPHS grant no. 26912-09.

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