MinireviewATP as a presynaptic modulator
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ATP-mediated signalling in the central synapses
2023, NeuropharmacologyPurinergic signaling orchestrating neuron-glia communication
2020, Pharmacological ResearchCitation Excerpt :Several peripheral function have been ascribed to this large family of P2Rs, namely in the control of inflammation [39], cancer [40] and vascular functions [41], which resulted in the development of a new class of antiplatelet medications blocking P2Y12Rs [42]. In contrast, although P2Rs are abundantly expressed in brain cells [43,44], the central effects of P2Rs are poorly understood, with the notable exception of nociception, where the brilliant work of Mark Salter and Kazu Inoue has identified P2X4R antagonists as promising future drug candidates to manage neuropathic pain [45,46]. Since ATP is now recognized as a generic danger signal in the periphery [47] and in the brain [6] there has been a great effort into exploring potential therapeutic opportunities of targeting P2Rs in pathological brain conditions, such as stroke (e.g. [48,49]), traumatic brain injury [50], epilepsy [51], Parkinson’s disease (e.g [52].)
Effects of pH on salicylic acid toxicity in terms of biomarkers determined in the marine gastropod Gibbula umbilicalis
2020, Marine Environmental ResearchEffect of high fat diets on the NTPDase, 5′-nucleotidase and acetylcholinesterase activities in the central nervous system
2018, International Journal of Developmental NeuroscienceCitation Excerpt :In addition, the 5′-nucleotidase enzyme promote the hydrolysis of AMP to adenosine, an important neuromodulatory messenger (Zimmermann, 2001). Studies demonstrated that ATP can control the acetylcholine release through a dual opposite modulation, acting on facilitatory P2X or inhibitory P2Y receptors (Cunha and Ribeiro, 2000). Moreover, considering that therapies to control the AD be based in use of AChE inhibitors, the association between the ATP hydrolysis and AChE activity could provide a fundamental link in the pathways to neurochemical disruption in AD.
Expression of ecto-nucleoside triphosphate diphosphohydrolase3 (NTPDase3) in the female rat brain during postnatal development
2016, Journal of Chemical Neuroanatomy