Elsevier

Life Sciences

Volume 60, Issues 4–5, 13 December 1996, Pages 245-251
Life Sciences

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Adenosine and neuronal plasticity

https://doi.org/10.1016/S0024-3205(96)00544-9Get rights and content

Abstract

Adenosine is considered an important neuromodulator of the nervous system acting at pre-, post- and non-synaptic levels. In the present review we describe how adenosine modifies paired-pulse facilitation (PPF), posttetanic depression (PTD), long-term potentiation (LTP), long-term depression (LTD) and depotentiation at the hippocampus, and therefore how this nucleoside modulates synaptic plasticity.

References (52)

  • J.A. Ribeiro et al.

    Prog. Neurobiol.

    (1986)
  • L. Jodar et al.

    Jpn. J. Pharmacol.

    (1995)
  • L.M. Grover et al.

    Neurosci. Lett.

    (1993)
  • Y. Sekino et al.

    Neurosci. Lett.

    (1992)
  • D.M. Lovinger et al.

    Neurosci. Lett.

    (1995)
  • A.C. Dolphin

    Neurosci. Lett.

    (1983)
  • A. De Mendonça et al.

    Neurosci. Lett.

    (1990)
  • A. Arai et al.

    Neurosci. Lett.

    (1990)
  • C. Alzheimer et al.

    Brain Res.

    (1991)
  • A. Arai et al.

    Brain Res.

    (1992)
  • A. De Mendonça et al.

    Neuroscience

    (1994)
  • A.M. Sebastião et al.

    Progr. Neurobiol.

    (1996)
  • Y. Sekino et al.

    Biochem. Biophys. Res. Comm.

    (1991)
  • D.J. Linden

    Neuron

    (1994)
  • M.Y. Xiao et al.

    Neuroscience

    (1995)
  • S. Fujii et al.

    Brain Res.

    (1991)
  • J. Larson et al.

    Brain Res.

    (1993)
  • S. Fujii et al.

    Neurosci. Lett.

    (1992)
  • R.M. Mulkey et al.

    Neuron

    (1992)
  • A. De Mendonça et al.

    Brain Res.

    (1993)
  • E.W. Harris et al.

    Neurosci. Lett

    (1986)
  • Y. Kuroda
  • E.R. Kandel et al.
  • B. Katz et al.

    J. Physiol.

    (1968)
  • D. Debanne et al.

    J. Physiol.

    (1996)
  • M. Andreasen et al.

    J. Neurophysiol.

    (1994)
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