Elsevier

Neuropharmacology

Volume 40, Issue 3, March 2001, Pages 457-459
Neuropharmacology

Rapid communication
Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

https://doi.org/10.1016/S0028-3908(00)00178-7Get rights and content

Abstract

Orexin A (10–300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 μM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy.

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