Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice
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Epileptic spasms in infancy: Transferring rat prenatal betamethasone-postnatal NMDA model to mice
2023, Neuroscience LettersThe interactions between reproductive hormones and epilepsy
2021, Handbook of Clinical NeurologyCitation Excerpt :The amygdala, in particular, can be parceled into two distinct cytoarchitectonic functional divisions that exert opposing modulatory influences on the hypothalamic regulation of pituitary gonadotropin secretion (Kaada, 1972; Herzog, 1989). The temporolimbic system also shows sensitive electrophysiologic responses to the feedback of neuroactive reproductive steroids (Fig. 11.5) (Herzog, 1989; Wong and Moss, 1992; Kokate et al., 1996). The potential role of epilepsy in the development of reproductive endocrine disorders has gained support from findings which suggest that the laterality and focality of the epilepsy may be associated with different specific types of reproductive endocrine disorders (Herzog, 1993; Gerendai and Halasz, 1997; Friedman et al., 2000; Herzog et al., 2003a,b; Kalinin and Zheleznova, 2007) and that altered neuroendocrine regulation may be a pathophysiologic mechanism (Fig. 11.6) (Bilo et al., 1991; Herzog et al., 2003a).
Realising the therapeutic potential of neuroactive steroid modulators of the GABA<inf>A</inf> receptor
2020, Neurobiology of StressZinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus
2019, NeuropharmacologyCitation Excerpt :Neurosteroids modulate GABA-A receptors primarily via allosteric potentiation of GABA at nanomolar concentrations and through direct activation of the channel at micromolar concentrations (Hosie et al., 2007). AP has powerful antiseizure activity (Kokate et al., 1996; Kaminski et al., 2003; Kaminski et al., 2004; Carver et al., 2016; Reddy and Estes, 2016). Ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one, GX), a synthetic analog of AP, is designed to treat epilepsy and related seizure conditions.