Rapid Communication8-OH-DPAT-induced Spontaneous Tail-flicks in the Rat are Facilitated by the Selective Serotonin (5-HT)2C Agonist, RO 60-0175: Blockade of its Actions by the Novel 5-HT2C Receptor Antagonist SB 206,553
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Cited by (27)
Spinal neurochemical mechanisms of acute stress-induced visceral hypersensitivity in healthy rats
2022, Neuroscience LettersCitation Excerpt :The current set of pharmacological studies sought to determine which spinal neurotransmitters are required for this facilitation. Previous studies related to the spinal mechanisms of descending facilitation have suggested a link to multiple neurotransmitters, including opioids, serotonin, noradrenaline, vasopressin, acetylcholine (nicotinic), corticotrophin-releasing factor (CRF; CRF1R agonists), and urocortins (CRF2R agonists) [5,15–25]. Therefore, following AFS or control procedures, separate groups of rats were intrathecally administered neurotransmitter receptor antagonists and subsequently examined for changes in VMRs to graded UBD.
Serotonin in Pain and Pain Control
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :In the spinal cord, 5-HT receptors are present on terminals of primary afferent neurons, on projection neurons, and on excitatory and inhibitory interneurons, which makes the action of 5-HT very complex. Accordingly, blockade or depletion of spinal 5-HT can enhance nociception (Millan et al., 1997; Pertovaara et al., 2001). Excellent reviews on this subject have been published recently (Millan, 2002; Suzuki et al., 2004b; Lopez-Garcia, 2006; Yoshimura and Furue, 2006).
Role of the 5-HT<inf>2C</inf> receptor in improving weight-supported stepping in adult rats spinalized as neonates
2006, Brain ResearchCitation Excerpt :The locomotor enhancing effect of mCPP is unlikely to involve the acute activation of the 5-HT1A receptor in adult rats spinalized as neonates. In fact, DPAT, a 5-HT1A receptor agonist not only reduced weight-supported stepping but has been shown to generate a set of stereotypic movements in these animals known as the serotonin syndrome (Shumsky et al., 2005) that was previously shown in normal animals to act through the 5-HT1A receptor (Lucki and Wieland, 1990; Millan et al., 1997). It is likely that the initiation of movements associated with the serotonin syndrome via the 5-HT1A receptor does not enhance locomotion, and may in fact hinder weight support by activating 5-HT1A receptors rostral to the site, producing postures that are incompatible with treadmill locomotion of an unrestrained rat.
Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release
2005, European Journal of Pharmacology