5 Cellular Mechanisms of Wingless/Wnt Signal Transduction
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Cited by (153)
Current Knowledge on the Role of Wnt Signaling Pathway in Glucose Homeostasis
2016, Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition SeriesGSK3β and the control of infectious bacterial diseases
2014, Trends in MicrobiologyNotch1-mediated signaling regulates proliferation of porcine satellite cells (PSCs)
2013, Cellular SignallingLysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin
2012, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :The canonical Wnt signaling pathway regulates several processes including early neoplasia. Wnt pathway activation stabilizes β-catenin and leads to its nuclear translocation and stimulation of β-catenin responsive target gene expression [11–15]. Aberrant β-catenin activation is associated with carcinogenesis.
Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT/β-catenin signaling is enhanced in irradiated medulloblastoma cells
2012, Journal of Biological ChemistryCitation Excerpt :Furthermore, IR treatment showed increased inactivation of GSK3β by phosphorylation at Ser-9 position (p < 0.01) (Fig. 1A). Inactivation of GSK3β leads to β-catenin stabilization and activation of β-catenin·TCF/LEF signaling (26). To determine whether IR-induced uPAR has a role in transcriptional activation of WNT/β-catenin signaling necessary for CSC, we performed real time PCR in control, Fl-uPAR, CSCs alone, and in combination with IR treatments.
Trenbolone enhances myogenic differentiation by enhancing β-catenin signaling in muscle-derived stem cells of cattle
2011, Domestic Animal EndocrinologyCitation Excerpt :The Wnt/β-catenin signaling pathway works through both frizzled and low-density lipoprotein receptor-related proteins, which leads to the inactivation of glycogen synthase kinase 3β and prevention of β-catenin degradation. In nuclei, β-catenin binds to TCF/LEF transcription factors to induce Wnt-targeted genes, including genes involved in myogenesis [44], Pax 3, and Gli [45,46], which then induce the expression of MyoD and Myf-5 [47-50]. β-Catenin was a primary mediator of the canonical Wnt/β-catenin signaling pathway, and increase in the cellular β-catenin content alone increases myogenesis [51,52].