Elsevier

Progress in Brain Research

Volume 166, 2007, Pages 19-35, 543
Progress in Brain Research

Pathophysiology of tinnitus

https://doi.org/10.1016/S0079-6123(07)66002-6Get rights and content

Abstract

Guided by findings from neural imaging and population responses in humans, where tinnitus is well characterized, several morphological and physiological substrates of tinnitus in animal studies are reviewed. These include changes in ion channels, receptor systems, single unit firing rate, and population responses. Most findings in humans can be interpreted as resulting from increased neural synchrony.

Introduction

Tinnitus is a percept that is well characterized in humans and also in some animal models. Here the approach to the pathophysiology of tinnitus will be to start with human tinnitus sufferers and to find differences in cochlear and brain function with those that do not suffer tinnitus. The available methods range from otoacoustic emissions to probe the cochlea, evoked potentials or evoked magnetic fields to reflect synchronous brain activity, and forms of functional imaging such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) that are largely reflecting the number of active neurons and their firing rates (Mukamel et al., 2005). A caveat in all these investigations is that tinnitus is most frequent in individuals with hearing loss, and this in itself causes changes in the cochlea (by definition) and in the brain (Don et al., 1998; Oates et al., 2002). Age typically introduces additional changes in the central nervous system (Tremblay et al., 2003) as does gender (Don et al., 1993). Thus, the tinnitus and non-tinnitus groups should preferably be matched for hearing loss, age and gender. Another caveat is that individual differences in evoked potential amplitude and functional images are often so profound that it is impossible to interpret the small changes observed. Therefore, studies where individuals serve as their own controls (unilateral tinnitus, gaze-induced tinnitus that can be controlled) are popular but the results may not be generalized easily. Furthermore, tinnitus as a percept is likely to depend on activity in the auditory cortices, even if the tinnitus generating structure is more peripheral. It is therefore useful to distinguish the tinnitus generation site from the site with the initial pathology, i.e., hair cell loss in the cochlea. We will call the tinnitus generation site, i.e., the site that is most peripheral in the auditory nervous system and that shows an accepted neural correlate of tinnitus, the ignition point (Eggermont, 2006). Here we have temporally neglected the important role of centrifugal cortical activity that, with some time delay, can cause changes in more peripheral structures. We will, as many others have done, equate the strength of the tinnitus sensation with the amount of deviance of the studied correlate from the norm. Correlates could for instance be the amplitude of evoked potentials, the size of the change in activated brain regions, or the incidence of spontaneous otoacoustic emissions.

PET studies in gaze-induced tinnitus suggest various correlates such as regional cerebral blood flow (rCBF) increase in the temporal-parietal auditory association areas (Brodman area: BA 22, 40, 42) but not in primary auditory cortex (PAC) (Giraud et al., 1999) and in addition activation in the auditory lateral pontine tegmentum (Lockwood et al., 2001). Absence of activation in PAC rules out significantly increased spontaneous firing rate (SFR) but does not rule out increased neural synchrony as a correlate of tinnitus. In fMRI studies of gaze-induced tinnitus (Cacace et al., 1996) foci of activity in the tinnitus patient were localized in the superior colliculus and frontal eye fields in cortex. Presently it is not clear whether this reflects activity related to the motor act (gaze) that induces tinnitus or to the percept of tinnitus itself. In patients able to modulate the loudness of their tinnitus by oral facial movements the loci of activity were in the auditory cortex (AC) contralateral to the ear in which the tinnitus was perceived as well as in limbic structures (Lockwood et al., 2001).

Lidocain infusion, which temporally suppresses tinnitus, produced equally likely increases or decreases in rCBF, but the changes were always larger for increases in the right temporal lobe of the auditory association cortex (Reyes et al., 2002), and this unilateral activation pattern suggests that the tinnitus originates centrally rather than peripherally. This is because for unilateral stimulation of a normal hearing subject there are always comparable changes in both hemispheres (Reyes et al., 2002). PET studies in groups of tinnitus patients with either Lidocain or with suppression of tinnitus by masking suggest that the baseline cortical activity in the right hemisphere regardless the lateralization of the tinnitus can be abnormally high in individuals with tinnitus (Mirz et al., 1999).

Using fMRI to determine the effect of tinnitus on the activity in the inferior colliculus (IC), Melcher et al. (2000) found a specific effect of masking noise: in unilateral tinnitus binaural noise produced an abnormally low further activation in the IC contralateral to the tinnitus ear. Since the amount of activation was calculated by comparing the brain oxygen level dependent (BOLD) response in the noise-masking condition to that without masking (but with tinnitus), one can interpret this by assuming that the tinnitus produces increased activation of the IC and that additional noise can only produce very little extra activation in the IC. Alternatives are that the noise masks the tinnitus and thus reduces its loudness and consequently its effect on IC activity. This finding suggests that neurons in the IC in individuals with tinnitus have a high-spontaneous activity. The authors noted that increased neural synchrony without increased SFR could not produce this effect.

Evidence for structural changes in individuals with tinnitus was found exclusively in the right posterior thalamus (including the medial geniculate body, MGB) where gray matter concentration was increased (Muhlau et al., 2006). This could point to increased dendritic arborization, potentially accompanied by increased synaptic density and the potential for increased spontaneous activity. It is interesting that the right auditory cortex, to which the right MGB projects, showed larger increases in activity compared to the left one.

The generation of tinnitus in many individuals is associated with decreased input to the auditory system caused by hearing loss. Various sources of evidence indicate that deprivation of primary auditory input leads to a slow-wave mode functioning of the central nervous system, i.e., analysis of electro-encephalogram (EEG) signals shows an enhanced power in the delta frequency range (<4 Hz). An example of such a condition is slow-wave sleep, during which thalamic (and thus also cortical) centers are partially cut off from input from prethalamic relays. This condition leads to a hyperpolarization of thalamocortical cells that activates sodium and potassium currents, gradually depolarizing the cell. The depolarization in turn triggers a calcium-mediated low-threshold spike burst. The frequency of this hyperpolarization spike-burst cycle is approximately in the delta to theta frequency range. Because of the cortico-thalamic connections, coherent slow-wave oscillations are also seen on a cortical level. The spontaneous cortical neuronal activity recorded as the magneto-encephalogram (MEG) in a group of individuals with tinnitus is characterized by a marked reduction in alpha (8–12 Hz) power together with an enhancement in delta (1.5–4 Hz) as compared to a normal hearing control group. This pattern was especially pronounced for temporal regions. Moreover, correlations with tinnitus-related distress revealed strong associations with this abnormal spontaneous activity pattern, particularly in right temporal and left frontal areas (Weisz et al., 2005a).

Ever since it was suggested that phantom limb pain was associated with changes in the topographic map in sensorimotor cortex (Flor et al., 1995), and that similar map changes in AC could underlie tinnitus (Mühlnickel et al., 1998) the search has been on for an unambiguous demonstration of such map changes. Most of the techniques used are based on the MEG and the maps are constructed on basis of equivalent dipole source locations for a series of frequencies. Albeit that this technique is fraud with pitfalls for those based on the N100 component because of contributions from multiple areas with opposite tonotopic gradients (Lütkenhöner et al., 2003b), it nevertheless suggest that consistent changes do occur. It appears that mapping based on middle latency responses (MLRs) that originate in PAC is more reliable (Lütkenhöner et al., 2003a). Diesch et al. (2004) using the steady-state evoked magnetic field that originates exclusively in PAC found enhanced activity in individuals with tinnitus compared to normal hearing controls. The enhancement correlated with the perceived intensity and intrusiveness of tinnitus. Wienbruch et al. (2006) used the 40-Hz auditory steady-state response (SSR) that also originates in PAC to compare the tonotopic frequency representations between individuals with chronic tinnitus and hearing impairment and normal hearing controls. The SSR frequency gradients were attenuated in both hemispheres in individuals with tinnitus. Dipole power was also elevated in tinnitus, suggesting that more neurons responded synchronously to the 40 Hz sound envelope. The altered frequency representations in tinnitus may reflect a loss of intracortical inhibition in partially deafferented frequency regions of the PAC after deprivation of input caused by cochlear injury. It is of course not clear if the map changes would have been different in a group of individuals with the same hearing loss but without tinnitus. The intricate interaction between hearing loss and tinnitus makes this difficult to study.

Attias et al. (1993) found that in individuals with tinnitus the event-related potentials (ERPs) (N100, P200 and P300), which originate largely from secondary and association cortices, were reduced in amplitude compared to what it was in hearing loss and age-matched controls. This could point to increased spontaneous activity in those areas so that stimulus-evoked activity can recruit fewer non-refractory neurons. Weisz et al. (2005b) compared individuals with tinnitus with controls and used tonal edge-frequency stimuli and tonal stimuli with a frequency one-octave below the edge. They found that the N100 dipole strength for individuals with tinnitus and controls was not different for edge-frequency tones but that the N100 responses were significantly larger for tonal stimuli with one-octave below the edge-frequency in the right hemisphere of the individuals with tinnitus. The source location for the edge-frequency dipole was abnormal, but in contrast to the Mühlnickel et al. (1998) findings, the deviation from the control position was not related to tinnitus distress. This suggests that map changes in itself cannot explain the strength of the tinnitus percept. The data from Weisz et al. (2005b) do suggest increased neural synchrony (larger N100), in contrast to the interpretation of the Attias et al. (1993) data, and enhanced right hemisphere activity as in the PET findings of Reyes et al. (2002) and Mirz et al. (1999). The differential hemispheric activity, with the strongest activity unrelated to the side of tinnitus is not explained by any bottom-up modeling of tinnitus (Eggermont and Roberts, 2004) and does suggest mechanisms potentially related to the differential representation of fast periodic (left hemisphere) vs. slow modulated or continuous (right hemisphere) sounds (Zatorre and Belin, 2001).

Gerken et al. (2001) did not find differences in the auditory brainstem response (ABR), except for the latency of wave VII, but they did observe exceptionally large amplitude of the MLR in their “problem tinnitus” group compared to a hearing loss group without tinnitus and an elderly group (where also large MLRs were found but not as consistent as in the tinnitus group). This could point to either increased neural synchrony, reduced central inhibition a known aspect of aging (Willott et al., 1997), or both.

Tinnitus can be considered as a positive symptom disorder characterized by “neuronal hyperactivity due to loss of afferent inhibition”, and has been linked to bursting neural activity in the medial thalamus. In one study, over 2000 single units (SUs) were recorded in the medial thalamus prior to medial thalamotomy in 104 patients, 6 of which had tinnitus. Approximately 99% of the 2000 SUs were unresponsive to sensory stimulation or motor activation, while 41% of the total showed rhythmic (at ∼4 Hz) or random burst-firing typical for low-threshold calcium spike bursts (Jeanmonod et al., 1996). These authors suggested a linkage between some forms of tinnitus and EEG spindling which is initiated by rhythmic bursting in the thalamus.

Spontaneous otoacoustic emissions are low-level sounds emitted by the healthy normal ear (outer hair cells) that are recordable with sensitive microphones inserted in the ear canal. In ∼6–12% (or at least 4% according to Penner and Jastreboff, 1996) of normal hearing persons spontaneous otoacoustic emissions are considered at least partially responsible for the tinnitus (Norton et al., 1990; Penner, 1990). Plinkert et al. (1990), elaborating on a proposal by Kemp (1981), speculated that the pathological long-term movements of a small local group of not more than 60 affected outer hair cells may account for tonal tinnitus. In most cases, however, spontaneous otoacoustic emissions and tinnitus are independent phenomena (Wilson and Sutton, 1981; Penner and Burns, 1987; Penner, 1992). Although spontaneous emissions could theoretically produce increased “spontaneous firing” in neurons innervating the basilar membrane at the emission site, central nervous system adaptation may preclude their audibility. Occasionally, however, some individuals have been reported to hear intermittent spontaneous otoacoustic emissions as intermittent tinnitus (Burns and Keefe, 1992).

In a patient with an overdose of salicylate, transient evoked otoacoustic emissions (TEOAE) were absent and distortion product otoacoustic emissions (DPOAE) were reduced but still present despite a 50 dB hearing loss, but the input-output functions were linearized suggesting a loss of outer hair cell functioning (Janssen et al., 2000). In individuals with tinnitus with normal hearing, DPOAE amplitudes were also reduced compared to normal hearing controls (Ozimek et al., 2006). Twenty-four hours after involuntary noise trauma in military personnel, TEOAE amplitudes were reduced when the tinnitus appeared to be long lasting and were a better predictor for persisting tinnitus than just the amount of hearing loss (Nottet et al., 2006). In contrast, in tinnitus resulting from head trauma in individuals with normal audiograms, the TEOAE amplitudes were increased, the incidence of spontaneous acoustic emission was doubled, and contralateral tinnitus suppression was reduced, all pointing to a potential deficit in the medial olivocochlear bundle activity (Ceranic et al., 1998). Thus, otoacoustic emissions are useful in the delineation of some mechanisms involved in cochlear functioning that might accompany tinnitus, but they do not generally relate to tinnitus itself.

Head and neck injuries are a profound cause of tinnitus, and in addition head and neck contractions can also modulate existing tinnitus in 80% of patients. More importantly in 60% of patients with no tinnitus at the time of testing such contractions could induce tinnitus even in the profoundly deaf (Levine et al., 2003). Møller et al. (1992) showed that median nerve stimulation could modulate existing tinnitus in 40% of ears, and Rubinstein (1993) showed that 33% of tinnitus patients could modulate their tinnitus with jaw movements. This suggests an important multi-modal aspect in the perception of tinnitus and points to different anatomical structures along the extra-lemniscal (non-classical pathways, see chapter 1) pathways, such as the external nucleus and cortex of the IC, and including the dorsal cochlear nucleus (DCN) as important ignition sites in the generation of tinnitus.

Studies in humans have shown abnormalities such as elevated delta waves in the spontaneous spectrum of the EEG or MEG, relatively enhanced activation in the right hemisphere, increased evoked-potential or evoked-magnetic field amplitude, tonotopic map changes in AC, structural changes in the right-sided thalamus and increased SFRs in the IC. Head trauma induced tinnitus may differ from that induced by noise trauma and the former may have a peripheral component. Multi-modal effects suggest involvement of the extra-lemniscal pathway, pointing to DCN, the external nucleus of the IC (ICx) and secondary auditory cortex (AII) as important potential ignition sites for tinnitus.

Section snippets

Tinnitus inducing agents: etiology

Causes of tinnitus in humans can be catalogued on basis of epidemiological and clinical studies. Henry et al. (2005) list overviews from several studies suggesting that noise trauma is the single most unique cause of tinnitus (18%), followed by head and neck trauma (8%) and ear, nose and throat (ENT) infections and illnesses (8%), whereas drugs only account for 2% of known incidents of tinnitus.

Tinnitus is thus often related to hearing loss resulting from external causes such as noise trauma

Putative neural correlates of tinnitus

The human studies reviewed above suggest changes in SFR (DCN and IC) and in neural synchrony (PAC) as correlates for tinnitus. Increased neural synchrony will be reflected in increased evoked potentials (or local field potentials, LFPs) as well as increased correlation in spiking times between simultaneously recorded neurons. Potentially other abnormalities in spontaneous firing such as increased burst firing cannot be excluded at this point. Another potential correlate of MEG studies suggested

Morphological and anatomical correlates of noise trauma

Exposure of chinchillas with a one-octave band of noise centered around 4 kHz and presented for 105 min at 108 dB sound pressure level (SPL) showed axonal degeneration in the DCN that peaked at 16 days post trauma (Bilak et al., 1996; Morest et al., 1998). However, in the auditory nerve (AN) and ventral cochlear nucleus (VCN) axonal degeneration continued for up to 8 months. This degeneration process was accompanied by an increase in small-diameter axons by up to 90% at 8 months post exposure (

Ion channels

The inner hair cells in the cochlea are equipped with only one type of Ca2+ channels, namely the L-type. These calcium channels regulate the release of glutamate from the inner hair cells. Blocking these L-type channels with nimodipine results in a decrease in spontaneous and stimulus-driven firing rates in AN fibers (Robertson and Paki, 2002). In the IC, salicylate appears to block this L-type Ca2+ channel (Liu et al., 2005). If salicylate would do the same in the inner hair cells, then one

Tonotopic map changes

Local mechanical damage to the cochlea (Robertson and Irvine, 1989; Rajan et al., 1993), ototoxic damage to the cochlea (Harrison et al., 1991), and noise-induced hearing loss all cause tonotopic map changes in PAC (Eggermont and Komiya, 2000; Seki and Eggermont, 2002; Noreña et al., 2003). The map changes are not causally related to the hearing loss (Noreña and Eggermont, 2005) and can occur in the absence of hearing loss as measured by ABR (Noreña et al., 2006) but are always accompanied by

What is the neural correlate of tinnitus?

In the bottom-up studies of tinnitus increased SFR and, to a lesser extent, neural synchrony have attracted most of the attention. It is doubtful whether increased SFRs in subcortical structures (DCN, IC) will lead to increased SFR in cortex. It is far more likely that increased neural synchrony in subcortical structures propagates along the auditory pathway (Kimpo et al., 2003) and ultimately result in increased synchrony and/or SFRs in cortex. Human studies using fMRI that find increased

Abbreviations

    AAF

    anterior auditory field

    ABR

    auditory brainstem response

    AC

    auditory cortex

    ACh

    acetylcholine

    AChR

    acetylcholine receptor

    AII

    secondary auditory cortex

    AMPA

    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

    AN

    auditory nerve

    AVCN

    anterior ventral cochlear nucleus

    BA

    Brodman area

    BOLD

    brain oxygen level dependent

    CAP

    compound action potential

    CF

    characteristic frequency

    ChAT

    cholineacetyl transferase

    CN

    cochlear nucleus

    DCN

    dorsal cochlear nucleus

    2-DG

    2-deoxyglucose

    DPOAE

    distortion product otoacoustic emission

    EEG

Acknowledgements

This study was supported by the Alberta Heritage Foundation for Medical Research, a Canadian Institutes of Health Research — NET grant, and the Campbell McLaurin Chair for Hearing Deficiencies.

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