Morphology of the Aging Brain, Human and Animal
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Cystatin C in aging and in Alzheimer's disease
2016, Ageing Research ReviewsCitation Excerpt :Similar to CysC staining of Aβ deposits in human brains, plaque-associated CysC immunoreactivity was restricted to a subpopulation of amyloid-laden vessels and was clearly less intense than Aβ immunolabeling (Levy et al., 2001; Steinhoff et al., 2001; Winkler et al., 2001). Neuropathologies characteristic of AD and normal aging in humans can also be seen in senescent non-human primates (Price et al., 1994; Walker et al., 1990; Wisniewski and Terry, 1973). For example, in aged rhesus monkeys (Macaca mulatta) amyloid deposition can occur in senile plaques with relatively minor vascular involvement whereas cerebrovascular deposits in aged squirrel monkeys (Saimiri sciureus) are usually more conspicuous than senile plaques (Walker et al., 1990).
Cortical complexity as a measure of age-related brain atrophy
2016, NeuroImageCitation Excerpt :As we age, the structure of our brain changes in numerous ways, ranging from vascularization to cellular (Kemper, 1994; Raz and Rodrigue, 2006; Wiśniewski and Terry, 1973).
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2013, Neurochemistry InternationalCitation Excerpt :β-amyloid (Aβ) deposition in the brain is well accepted as a pathological hallmark of Alzheimer’s disease (AD), although there is considerable diversity of opinions regarding the significance of plaque generation in relation to the etiopathogenesis of the disease (O’Brien and Wong, 2010; Kocherhans et al., 2010; Chakrabarty et al., 2010a, 2010b). The heterogeneity of plaque morphology has also been noted by a number of early investigators in the field of AD research (Wisniewski and Terry, 1973; Ulrich, 1985), although the significance of these plaque isoforms attached to the pathomechanisms of the disease is yet to be determined (Armstrong, 1998; Dickson and Vickers, 2001; D’Andrea and Nagele, 2010; Chlan-Fourney et al., 2011). Of the many descriptive names for plaques presented in the literature, two of the most common subtypes viz. dense-core and diffuse types, have generally been classified based on their distinctive appearance in the immunohistochemical preparations of postmortem AD brains (D’Andrea and Nagele, 2010).
Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APP<inf>swe</inf>/PS1<inf>ΔE9</inf> double transgenic mice
2011, Brain ResearchCitation Excerpt :Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by progressive memory loss, cognitive decline and widespread loss of neurons and their synapses in the cerebral cortex, entorhinal area, hippocampus, ventral striatum and basal forebrain (Selkoe, 2001 and Wisniewski and Terry, 1973).
Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
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