ArticlesCocaine Reward and Locomotor Activity in C57BL/6J and 129/SvJ Inbred Mice and Their F1 Cross
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Animals and Drugs
C57BL/6J and 129/SvJ were obtained from Jackson Laboratories (Bar Harbor, ME, USA) and maintained in the animal colonies of the Molecular Genetics Section of NIDA/Division of Intramural Research (Baltimore, MD, USA). Animals were housed in groups of generally five or six animals per cage; food and water were freely available, and the mice were maintained on a 12 L : 12 D cycle (lights on at 0700 h), in accordance with guidelines of the American Association for Laboratory Animal Care. All
Spontaneous Locomotor Activity and Development of Habituation
The C57BL/6J strain and the C57 × 129 F1 animals are significantly more active than the 129/SvJ strain, with three times the total distance traveled in a 30-min period (Fig. 1A) [F(2, 20) = 40.02, p < 0.0001; Bonferroni–Dunn post hoc, p < 0.0001]. Because F1 mice are heterozygous at all loci for which their progenitor strains differ, their response is determined by both additive genetic effects and the nonadditive effects of dominance and genic interaction. If the genes influencing locomotor
Discussion
As this and previous studies have so thoroughly demonstrated, the genetic makeup of an animal can greatly influence a variety of behaviors, including response to drugs of abuse 5, 6, 12, 17, 18. The present study characterizes cocaine response in a previously uncharacterized mouse strain, 129/SvJ, as well as in the widely used C57BL/6J strain and in F1 animals derived from them. This characterization and future studies focusing on other pharmacological agents will lay the foundation for a
Acknowledgements
I thank Jennifer Mulle for assistance in the conditioned place preference experiments and Linda Roggio for animal breeding assistance.
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