Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1–17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus
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2022, Progress in Molecular Biology and Translational ScienceEndogenous dynorphins, glutamate and N-methyl-d-aspartate (NMDA) receptors may participate in a stress-mediated Type-I auditory neural exacerbation of tinnitus
2013, Brain ResearchCitation Excerpt :Therefore, the NMDA receptor appears to be a likely mediator of many of the antinociceptive actions of opioids in general and a likely mediator of many non-analgesic actions of dynorphins in particular (Lai et al., 2001; Laughlin et al., 1997; Vanderah et al., 1996), as indicated in the sections that follow. Considerable evidence indicates that κ-opioid ligands interact directly with the NMDA receptor (Hauser et al., 1999; Schwarzer, 2009; Shukla and Lemaire, 1994; Tang et al., 1999) either at a glycine site (Voorne et al., 2007) or quite possibly at multiple binding sites (Caudle and Dubner, 1998; Chen et al., 1995; Laughlin et al., 2001; Tan-No et al., 2002; Woods et al., 2006; Zhang et al., 1997). A distinct high affinity dynorphin binding site has also been detected on the NMDA receptor in rat cortex (Tang et al., 1999).
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