Triggers and substrates of hippocampal synaptic plasticity

doi:10.1016/S0149-7634(05)80034-X

Neuroscience & Biobehavioral Reviews

Volume 15, Issue 3, Autumn 1991, Pages 415-423

https://doi.org/10.1016/S0149-7634(05)80034-X Get rights and content

It is widely assumed that behavioral learning reflects adaptive properties of the neuronal networks underlying behavior. Adaptive properties of networks in turn arise from the existence of biochemical mechanisms that regulate the efficacy of synaptic transmission. Considerable progress has been made in the elucidation of the mechanisms involved in synaptic plasticity at central synapses and especially those responsible for the phenomenon of long-term potentiation (LTP) of synaptic transmission in hippocampus. While the nature and the timing requirements of the triggering steps are reasonably well known, there is still a lot of uncertainty concerning the mechanisms responsible for the long-term changes. Several biochemical processes have been proposed to play critical roles in promoting long-lasting modifications of synaptic efficacy. This review examines first the triggers that are necessary to produce LTP in the hippocampus and then the different biochemical processes that have been considered to participate in the maintenance of LTP. Finally, we examine the relationships between LTP and behavioral learning.

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Triggers and substrates of hippocampal synaptic plasticity

Brain Res.

J. Biol. Chem.

Science

Neurosci. Lett.

Behav. Neural Biol.

J. Neurol. Sci.

Brain Res.

Brain Res.

Biochim. Biophys. Acta

Brain Res.

Neuroscience

Neurosci. Lett.

Neurosci. Lett.

Neurosci. Res.

Neuron

Science

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Neuroscience

Brain Res.

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Cell

Neuroscience

Toxicon

Brain Res.

Brain Res.

Neurosci. Lett.

Biochem. Pharmacol.

Brain Res.

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

Science

Calcium-mediated reduction of ionic currents: a biophysical memory trace

Science

Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus

Nature

Properties and substates of mammalian memory systems

Opposite effects of PLA2 on 3H-AMPA binding in adult and neonatal membranes

Dev. Brain Res.

Presynaptic mechanism for long-term potentiation in the hippocampus

Nature

Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning

Science

Identification of the pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning

Neurotransmitter plasticity at the molecular level

Science

Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anesthetized rats

J. Physiol. (Lond.)

Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetize rabbit following stimulation of the perforant path

J. Physiol.

Long-term potentiation: mechanisms and properties

Correlation between 31P NMR phosphomonoester and biochemically determined phosphorylethanolamine and phosphatidylethanolamine during development of the rat brain

Dev. Neurosci.

The neural and molecular bases of learning

Dahlem Konferenzen

Preserved learning and retention of pattern-analyzing skill in amnesia: Dissociation of knowing how and knowing what

Science

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

Nature

The antagonism of amino acid-induced excitations of rat hippocampal CAI neurones in vitro

J. Physiol. (Lond.)

Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus

J. Physiol. (Lond.)

Opposite effects of PLA₂ on ³H-AMPA binding in adult and neonatal membranes