Catalysis of the disproportionation of superoxide by metalloporphyrins. III

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Abstract

An assay based on the use of an oxygen electrode has been used to determine the superoxide dismutase-type activity of several metalloporphyrins. Both the iron(III) and manganese(III) derivatives of tetrakis-(4-N-methylpyridyl)porphine were shown to have comparable activity, about 2-3% of that of the enzyme. Comparisons are made between this assay method and the more standard one which depends on the conversion of nitroblue tetrazolium to formazan.

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Paper I: R.F. Pasternack and B. Halliwell, J. Am. Chem. Soc. 101, 1026 (1979); paper II: R.F. Pasternack and W.R. Skowronek, Jr., J. Inorg. Biochem. 11, 261 (1979).

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