The effect of intrahippocampally applied anisomycin on the retention of brightness discrimination in rats1

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Intrahippocampal application of the protein synthesis inhibitor anisomycin impaired the retention performance of a brightness discrimination task in rats. A proactive effect of anisomycin could be excluded. The impairment of retention was not due to disturbing effects on locomotor activity. The same dosage of anisomycin caused a reduction in leucine incorporation into hippocampal proteins to approximately 6–9%. The present findings suggest that consolidation processes acting during and for a few hours after training may be impaired by inhibition of protein synthesis in the hippocampus.

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This work was supported by the Ministry of Science and Technology of the G. D. R. We gratefully acknowledge the skillful technical assistance of Frau L. Enderling and Frau E. Mentel.

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