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Infusion of the metabotropic receptor agonist, DCG-IV, into the main olfactory bulb induces olfactory preference learning in rat pups

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Abstract

DCG-IV, a type 2 metabotropic glutamate receptor (mGluR2) agonist, was infused into the main olfactory bulb of 1-week-old pups exposed to peppermint odor. A preference for peppermint was demonstrated 24 h later. The data support the proposal that disinhibition at dendrodendritic synapses between granule cells and mitral cells is a critical component of olfactory memory formation in the rat pup olfactory bulb as well as in the accessory olfactory bulb of adult rodents.

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Acknowledgements

We wish to thank the Canadian Institute of Health Research and CEDA Regional Partnership (ROP14148) for grant support.

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    Activation of β-adrenoceptors (as the unconditioned stimulus, US), paired with a novel odor (as the conditioned stimulus, CS), is both necessary and sufficient for the expression of a preference for the odor 24 h later (Sullivan, McGaugh, & Leon, 1991). We (Langdon, Harley, & McLean, 1997; Rumsey, Darby-King, Harley, & McLean, 2001; Yuan, Harley, Darby-King, Neve, & McLean, 2003) and others (Moriceau & Sullivan, 2004) have shown that manipulations limited to the olfactory bulb are sufficient to induce or prevent early odor preference learning. In the present experiments, intrabulbar infusions of protein synthesis inhibitors for translation (anisomycin) and transcription (actinomycin) given immediately after training were used to explore the protein synthesis requirements of 3 h, 5 h and 24 h odor preference memory in rat pups.

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