News & Comment
The nigrostriatal dopamine system: a neglected target for 5-HT2C receptors

https://doi.org/10.1016/S0165-6147(00)01811-3Get rights and content

Section snippets

Chemical names

MK2126-chloro-2-(1-piperazinyl)piperazine
Ro600175(S)-2-(6-chloro-5-fluoro-indol-1-yl)-1-methyl-ethylamine
SB2065535-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole
SB2420846-chloro-5-methyl-1-[2-(2-methylpyridiyl-3-oxy)-pyrid-5-yl carbamoyl]-indoline

Cited by (37)

  • Where in the serotonergic system does it go wrong? Unravelling the route by which the serotonergic system affects feather pecking in chickens

    2018, Neuroscience and Biobehavioral Reviews
    Citation Excerpt :

    It is known that 5-HT receptors can influence DA release from mesolimbic dopaminergic neurons in mammals (Fink and Göthert, 2007). The postsynaptic 5-HT1A receptor is a major modulator for striatal DA activity (De Deurwaerdère and Di Giovanni, 2017), but also 5-HT2 receptors play an important role in DA release in the NAc (De Deurwaerdère and Spampinato, 2001). Also in chicken, explicit roles for the somatodendritic 5-HT1A autoreceptor and postsynaptic 5-HT1B receptor in DA activity have been found (Dennis et al., 2013a).

  • Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications

    2017, Progress in Neurobiology
    Citation Excerpt :

    It is remarkable that the 5-HT2C receptor-dependent inhibitory effect is not observed when endogenous 5-HT tone is increased (De Deurwaerdere and Spampinato, 1999). Conversely, the systemic administration of numerous drugs sharing the ability to block 5-HT2C receptors such as SB-206553, SB-242084, SB-243413 have been shown to enhance DA release in the cortex, NAc and striatum (Berg et al., 2006; De Deurwaerdere et al., 2004; De Deurwaerdere and Spampinato, 2001; Gobert et al., 2000; Hovelso et al., 2011; Navailles et al., 2006a; Visser et al., 2015). Although this could suggest the existence of a tonic inhibitory control on DA function exerted by 5-HT on 5-HT2C receptors, one has to question why it does not similarly occur with all 5-HT2C antagonists.

  • 5-HT2C receptors in psychiatric disorders: A review

    2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry
    Citation Excerpt :

    5-HT2CR stimulation may partly modulate the neurochemical and behavioral effects of psychostimulants by altering accumbal DA and/or glutamate levels (Pandey et al., 2006). The inhibitory activity of the dopaminergic pathways projecting to the FC, the mesolimbic and nigrostriatal pathways innervating the NAc and striatum can be modulated by receptors 5-HT2C (Alex and Pehek, 2007; De Deurwaerdere and Spampinato, 2001; Gobert et al., 2000; Millan et al., 2000b). It seems that activity of mesocortical/mesolimbic dopaminergic and noradrenergic projections (neurons) are under the control of a tonic and phasic inhibitory of 5-HT2CRs, (Di Matteo et al., 1999, 2000b; Millan et al., 1998).

View all citing articles on Scopus
View full text