Trends in Neurosciences
Volume 23, Issue 9, 1 September 2000, Pages 410-411
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Confusion between neuronal apoptosis and activation of programmed cell death mechanisms in acute necrotic insults

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References (23)

  • C. Ikonomidou

    Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

    Science

    (1999)
  • Cited by (54)

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      The result demonstrates that salivary amylase activity may be a candidate indicator of the body LPS infection. The pituitary–adrenal axis is well-known for its role in response to stress, and increasing evidence shows the importance of the cortisol response during stress (Roy and Sapolsky, 2000; Merlot et al., 2013). In a previous study, salivary cortisol was used as a biomarker to evaluate humans stress (Fekedulegn et al., 2012).

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      However, in light of the biochemical data showing early activation of classic apoptosis programs, abundant ultrastructural evidence of incomplete processing and packaging of cytoskeletal and nuclear components, data that active caspase-3 are expressed in dying neurons lacking the full apoptosis phenotype and evidence for early and severe mitochondrial dysfunction in the forebrain following neonatal HI, we propose that the intermediate continuum phenotype of neurodegeneration occurring acutely following neonatal HI represents activation and then interruption of an apoptosis signaling pathway and is the most common phenotype of neurodegeneration occurring acutely in the developing striatum following neonatal HI. Arguments against the cell death continuum (Ishimaru et al., 1999; Fujikawa, 2000) are based on the assumption that morphology and underlying biochemical processes are discrete. While this may be true at extremes of the cell death continuum, absolute discreteness ignores the cellular appearances that are seen in response to acute injury to the newborn brain.

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