Trends in Neurosciences
Letters to EditorConfusion between neuronal apoptosis and activation of programmed cell death mechanisms in acute necrotic insults
References (23)
- et al.
Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?
Trends Neurosci.
(1999) Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms
Neuroscience
(2000)- et al.
Preincubation with protein synthesis inhibitors protects cortical neurons against oxygen–glucose deprivation-induced death
Neuroscience
(1996) Evidence for an active type of cell death with ultrastructural features distinct from apoptosis: the effects of 3-acetylpyridine neurotoxicity
Neuroscience
(1997)Amyloid-beta protein induces necrotic cell death mediated by ICE cascade in PC12 cells
Exp. Cell Res.
(1997)Cell death: the significance of apoptosis
Int. Rev. Cytol.
(1980)- et al.
Anoxic-ischaemic cell change in rat brain: light microscopic and fine-structural observations
J. Neurol. Sci.
(1972) - et al.
Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus
Mol. Brain Res.
(2000) Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis continuum
J. Comp. Neurol.
(1997)Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum
J. Comp. Neurol.
(1997)
Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
Science
Cited by (54)
Response to lipopolysaccharide in salivary components and the submandibular gland of pigs
2014, Livestock ScienceCitation Excerpt :The result demonstrates that salivary amylase activity may be a candidate indicator of the body LPS infection. The pituitary–adrenal axis is well-known for its role in response to stress, and increasing evidence shows the importance of the cortisol response during stress (Roy and Sapolsky, 2000; Merlot et al., 2013). In a previous study, salivary cortisol was used as a biomarker to evaluate humans stress (Fekedulegn et al., 2012).
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath
2008, Molecular and Cellular NeuroscienceThe AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
2008, Leukemia ResearchFailure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain
2007, NeuroscienceCitation Excerpt :However, in light of the biochemical data showing early activation of classic apoptosis programs, abundant ultrastructural evidence of incomplete processing and packaging of cytoskeletal and nuclear components, data that active caspase-3 are expressed in dying neurons lacking the full apoptosis phenotype and evidence for early and severe mitochondrial dysfunction in the forebrain following neonatal HI, we propose that the intermediate continuum phenotype of neurodegeneration occurring acutely following neonatal HI represents activation and then interruption of an apoptosis signaling pathway and is the most common phenotype of neurodegeneration occurring acutely in the developing striatum following neonatal HI. Arguments against the cell death continuum (Ishimaru et al., 1999; Fujikawa, 2000) are based on the assumption that morphology and underlying biochemical processes are discrete. While this may be true at extremes of the cell death continuum, absolute discreteness ignores the cellular appearances that are seen in response to acute injury to the newborn brain.