Trends in Neurosciences
Research updateBDNF as an anterophin; a novel neurotrophic relationship between brain neurons
References (19)
Detection of brain-derived neurotrophic factor in a vesicular fraction of brain synaptosomes
J. Biol. Chem.
(1997)Rapid alterations of BDNF protein levels in the rat brain after focal ischemia: evidence for increased synthesis and anterograde axonal transport
Exp. Neurol.
(1998)- et al.
Dysfunction of rat forebrain astrocytes in culture alters cytokine and neurotrophic factor release
Neurosci. Lett.
(2000) Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons
Mol. Cell Neurosci.
(1996)Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons
Dev. Biol.
(1994)Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth
Neuron
(1997)Neurotrophins and activity-dependent plasticity
Prog. Brain Res.
(2000)Biological characterization and optical imaging of brain-derived neurotrophic factor–green fluorescent protein suggest an activity-dependent local release of brain-derived neurotrophic factor in neurites of cultured hippocampal neurons
J. Neurosci. Res.
(2001)Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons
Science
(2001)
Cited by (51)
Involvement of PI3K/Akt/GSK-3β and mTOR in the antidepressant-like effect of atorvastatin in mice
2016, Journal of Psychiatric ResearchCitation Excerpt :Since classical antidepressants like fluoxetine, sertraline and imipramine and even electroconvulsive shock do not influence mTOR signaling (Park et al., 2014), it seems to be a mechanism mediated by drugs that modulate glutamatergic system, like ketamine (Li et al., 2010) and atorvastatin. Among several growth factors, Brain Derived Neurothrophic Factor (BDNF) is the most prominent one in the CNS (Nawa and Takei, 2001) and it has been shown to activate mTOR signaling (Takei et al., 2001) as well as PI3K/Akt pathway (Lang et al., 2007; Mizuno et al., 2003). In a previous study we demonstrated that acute atorvastatin treatment is able to increase hippocampal BDNF levels (Ludka et al., 2013).
Progesterone effects on neuronal brain-derived neurotrophic factor and glial cells during progression of Wobbler mouse neurodegeneration
2012, NeuroscienceCitation Excerpt :BDNF is stored in neuronal vesicles, which are bidirectionally transported to pre- and postsynaptic sites (Matsuda et al., 2009). Neurite-released BDNF may serve a neurotransmitter function or become a trophic factor for second and third order neurons and for oligodendrocytes (Altar and DiStefano, 1998; Nawa and Takei, 2001; von Bartheld et al., 2001; Ng et al., 2007; Salio et al., 2007). The progesterone-induced depletion of BDNF observed by ELISA in ventral horns and by immunocytochemistry in motoneurons, occurred equally in control as well as Wobbler mice, favoring the release hypothesis.