Elsevier

Neurobiology of Aging

Volume 22, Issue 1, January 2001, Pages 123-126
Neurobiology of Aging

Commentary
PHF and PHF-like fibrils –cause or consequence?

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      These include AD; frontotemporal lobar degeneration with tau inclusions (FTLD-tau) such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration; agyrophillic grain disease; some prion diseases; amyotrophic lateral sclerosis/parkinsonism-dementia complex; chronic traumatic encephalopathy; and some genetic forms of Parkinson's disease (Lee et al., 2001; Omalu et al., 2011; Rajput et al., 2006; Santpere and Ferrer, 2009). Although associations per se cannot prove cause-effect relationships, tau inclusions are widely thought to contribute to the pathogenesis of these disorders because they occur in specific brain regions whose functions are altered by these conditions, and NFT formation correlates with the duration and progression of AD (Giannakopoulos et al., 2003; Ihara, 2001). Tau inclusions also appear to modulate the clinical features of other neurodegenerative diseases.

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