Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

doi:10.1016/S0278-5846(00)00129-9

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volume 24, Issue 7, October 2000, Pages 1053-1067

https://doi.org/10.1016/S0278-5846(00)00129-9 Get rights and content

Abstract

1.
1. Different animal tests model different anxiety disorders. Thus, the social interaction test is a model of generalised anxiety disorder, plus-maze Trial 1 models elements of panic disorder and Trial 2 in the elevated plus-maze is a model of specific phobia.
2.
2. Studies of the neuroanatomical and neurochemical pathways controlling behaviour in these different tests provides information on the neurobiological mechanisms modulating anxiety disorders.
3.
3. In the social interaction test, nicotine and 8-OH-DPAT had anxiogenic effects when injected into the dorsal hippocampus or the lateral septum.
4.
4. These ligands were without effect on Trial 1 in the plus-maze when injected into the dorsal hippocampus, but had anxiogenic effects when injected into the lateral septum.
5.
5. On Trial 2 in the elevated plus-maze, nicotine had an anxiolytic effect, but 8-OH-DPAT had an aaxiogenic effect when injected into the dorsal hippocampus.

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Critical review and theoritical paperHippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

Abstract

Brain Res.

Eur. J. Pharmacol.

Brain Res. Bull.

Pharmacol. Biochem. Behav.

J. Neurosci. Methods

Brain Res.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Neuropsychopharmacology

Neuropsychopharmacology

Brain Res.

Behav Brain Res

Neurosci. Biobehav. Rev

Neuropharmacology

Neuropharmacology

Eur. J. Pharmacol.

Pharmacol. Biochem. Behav.

Neurosci. Biobehav. Rev

Mol. Brain Res.

J. Neurosci. Methods

Pharmacol. Biochem.& Behav.

Physiol. & Behav.

Neuropharmacology

Physiol. & Behav.

Pharmacol. Biochem. Behav.

DSM IV R-Diagnostic and Statistical Manual of Psychiatrie disorders

Neuronal nicotinic acetylcholine receptors novel targets for central nervous system therapeutics

Nicotinic hinging in rat brain autoradiographic comparison of [3H]-acetylcholine, [3H]nicotine, and [125I]-L-Bungarotoxin

J. Neurosci.

Can social interaction be used to measure anxiety?

Brit J Pharmacol

One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus- maze

Psychopharmacology

Characterisation of the phenomenon of ‘one-trial tolerance’ to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze

Psychopharmacology

Behavioural detection of anxiolytic action

⪡ One-trial tolerance ⪢ to the anxiolytic actions of benzodiazepines in the elevated plus-maze, or the development of a phobic state?

Psychopharmacology

Critical review and theoritical paper
Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

Nicotinic hinging in rat brain autoradiographic comparison of [³H]-acetylcholine, [³H]nicotine, and [¹²⁵I]-L-Bungarotoxin