Comparative Biochemistry and Physiology Part A: Physiology
ReviewMetabolic regulation in mammalian hibernation: Enzyme and protein adaptations☆
References (46)
- et al.
Heat resistance and heat-shock protein synthesis in a reptilian cell line, lgH-2, from Iguana iguana
J. Therm. Biol.
(1990) - et al.
Changes in kinetics of ATP-synthetase and in concentrations of adenine nucleotides in ground squirrel liver mitochondria during hibernation
Comp. Biochem. Physiol.
(1990) - et al.
The effects of short term cold storage upon ATP and 2,3-BPG levels in the blood of euthermic and hibernating thirteen-lined ground squirrels Spermophilus tridecemlineatus
Comp. Biochem. Physiol.
(1993) - et al.
Regulation of the skeletal muscle metabolism during hibernation of Jaculus orientalis
Comp. Biochem. Physiol.
(1990) - et al.
Inhibition of succinate oxidation and K+ transport in mitochondria during hibernation
Comp. Biochem. Physiol.
(1985) - et al.
Hepatic gluconeogenesis and mitochondrial function during hibernation
Comp. Biochem. Physiol.
(1988) - et al.
Cold shock elicits expression of heat shock proteins in the flesh fly, Sarcophaga crassipalpis
J. Insect Physiol.
(1990) - et al.
Identification of novel blood proteins specific for mammalian hibernation
J. Biol. Chem.
(1992) Pharmacological aspects of mammalian hibernation
Pharm. Ther.
(1984)Enzymes of heterotherms: LDH of hibernating and normothermic little brown bats, Myotis lucifugus
Comp. Biochem. Physiol.
(1978)
Pyruvate dehydrogenase
Regulation of liver metabolism by enzyme phosphorylation during mammalian hibernation
J. Biol. Chem.
Metabolic adaptations supporting anoxia tolerance in reptiles: Recent advances
Comp. Biochem. Physiol. B
Monoclonal antibody ELISA test indicates that large amounts of constitutive hsp-70 are present in salamanders, turtle and fish
J. Therm. Biol.
Fatty acid synthetase in control, starved, and refed Richardson's ground squirrels
Comp. Biochem. Physiol.
Regulation of the mitochondrial adenine nucleotide pool size in liver: Mechanism and metabolic role
FASEB J.
Enzymes of the normothermic and hibernating bat, Myotis lucifugus: Temperature as a modulator of pyruvate kinase
J. Comp. Physiol.
Mechanisms of glycolytic control during hibernation in the ground squirrel Spermophilus lateralis
J. Comp. Physiol.
Role of chilling in the acquisition of cold tolerance and the capacitation to express stress proteins in diapausing pharate larvae of the gypsy moth, Lymantria dispar
Arch. Insect Biochem. Physiol.
The effect of fructose-2,6-bisphosphate and AMP on the activity of phosphorylated and unphosphorylated fructose-1,6-bisphosphatase from rat liver
FEBS Lett.
Reduction of metabolism during hibernation and daily torpor in mammals and birds: Temperature effect or physiological inhibition
J. Comp. Physiol.
Cited by (124)
Bat-derived cells use glucose as a cryoprotectant
2023, Journal of Thermal BiologyHepatic citrate synthase suppression in the freeze-tolerant wood frog (Rana sylvatica)
2023, International Journal of Biological MacromoleculesStrategies of biochemical adaptation for hibernation in a South American marsupial, Dromiciops gliroides: 4. Regulation of pyruvate dehydrogenase complex and metabolic fuel selection
2018, Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular BiologyCitation Excerpt :As the major metabolic center of the body and the largest site of glycogen storage, liver regulates the glucose supply to most organs, as well as catalyzing a host of other functions that are vital for hibernation survival, including ketogenesis, gluconeogenesis, and detoxification of xenobiotics. A strong reduction in liver PDH activity and increased reliance on fatty acid oxidation is part of the glucose sparing effect, in which liver glycogen stores are reserved to supply tissues that have a continuing high reliance on glucose, such as brain and red blood cells (Storey, 1997; Storey and Storey, 2010; Wijenayake et al., 2017). Although glucose sparing is clearly indicated by our results for PDH regulation during hibernation in D. gliroides, other lines of evidence that would support this are still unresolved.
Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system
2018, Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular BiologyInvestigating Nrf2-associated non-coding RNAs in the hibernating ground squirrel, Ictidomys tridecemlineatus
2018, Journal of Thermal BiologyCitation Excerpt :The current functional approach also identified processes linked with protein phosphorylation and dephosphorylation. This observation is in line with multiple reports that highlighted the underlying importance of reversible protein phosphorylation on enzyme activities in hibernation and how it can impact ultimately metabolic rate depression during this process (Storey, 1997). Overall, the approach undertaken to better characterize the transcript targets associated with the miRNAs investigated in the current work highlighted a series of processes relevant for mammalian hibernation.
- ☆
Supported by a research grant from the N.S.E.R.C. Canada.