Elsevier

Neuroscience Letters

Volume 295, Issues 1–2, 1 December 2000, Pages 17-20
Neuroscience Letters

In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoids

https://doi.org/10.1016/S0304-3940(00)01580-9Get rights and content

Abstract

The mature central nervous system contains precursor cells in the subventricular zone of the lateral ventricle. In this study we examined the possibility to affect fate of precursor cells through exogenous manipulations. The results indicate that administration of thyroid hormone and retinoic acid increases the expression of Ki67, a nuclear antigen associated with cell proliferation, and of nestin, a marker protein for precursor cells in the subventricular zone of adult male rats. Moreover, retinoic acid increases polysialated-neural cell adhesion molecules (PSA-NCAM)-immunoreactivity. These data suggest that nuclear receptor ligands are potential candidates for fate determination of precursor cells in the subventricular zone also in the adult brain.

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Acknowledgements

Supported by Telethon 1052, MURST cofinanziamento 1999 e Fondazione Italiana Sclerosi Multipla (FISM/AISM) (L.C.)

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