In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoids
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Acknowledgements
Supported by Telethon 1052, MURST cofinanziamento 1999 e Fondazione Italiana Sclerosi Multipla (FISM/AISM) (L.C.)
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2005, Schizophrenia ResearchStem cells and nervous tissue repair: From in vitro to in vivo
2004, Progress in Brain ResearchCitation Excerpt :However, as recently pointed out by several authors, BrdU marks DNA synthesis, not division: therefore more rigorous criteria should be applied to allow speculation on gliogenesis and neurogenesis in the adult brain (Cameron and McKay, 2001; Gould and Gross, 2002; Rakic, 2002). More recently, we and other authors have proposed immunolabeling of antigens normally expressed by cycling cells, like Ki67 (Fig. 1B, F) (Calzà et al., 1998; Giardino et al., 2000; Kee et al., 2002) or PCNA (Redmond et al., 1996); this procedure provides a useful tool for double labeling experiments, though it does not solve all specificity issues. Lining the wall of the lateral ventricle in the adult mammalian brain, lies a large germinal zone, named subventricular zone (SVZ) (Luskin, 1993; Morshead et al., 1994), which has been extensively characterized in rodents (Doetsch and Alvarez-Buylla, 1996; Lois et al., 1996; Doetsch et al., 1997; Alvarez-Buylla and Garcia-Verdugo, 2002).
Nestin expression after experimental intracerebral hemorrhage
2003, Brain ResearchCitation Excerpt :In the current ICH study, the neuron-like cells were also positive for Ki-67, a marker of cell proliferation. Previous reports have co-localized nestin immunoreactivity with Ki-67 [10,35] and 5-bromo-2-deoxyuridine (BrdU) [19,43], another marker of cell proliferation. Kee et al. showed that Ki-67 and BrdU are useful markers of proliferation during adult neurogenesis [18].