Elsevier

Neuroscience Letters

Volume 297, Issue 2, 12 January 2001, Pages 105-108
Neuroscience Letters

Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues

https://doi.org/10.1016/S0304-3940(00)01679-7Get rights and content

Abstract

We investigated immunohistochemically the localization of type 1 plasminogen activator inhibitor (PAI-1) in rat and human brain tissues. In rat, neurons and astrocytes were stained positively for PAI-1 after colchicine treatment. In post-mortem human brain, neurons were stained for PAI-1 but the number of positive neurons varied greatly from case to case. PAI-1 positive astrocytes occurred in the white matter lesions of some patients. In Alzheimer's disease, weak PAI-1 labeling was seen in association with senile plaques and ghost tangles. The present results support a notion that PAI-1 and its target proteases such as plasminogen activators and thrombin are involved in a variety of physiological and pathological processes in brain.

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Acknowledgements

This research was supported by grants-in-aid from the Ministry of Education, Science, Sports and Culture of Japan (10670618).

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