Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain

doi:10.1016/S0304-3940(01)02060-2

Neuroscience Letters

Volume 310, Issues 2–3, 14 September 2001, Pages 101-104

https://doi.org/10.1016/S0304-3940(01)02060-2 Get rights and content

Abstract

The present study addresses the question whether local glucose transport kinetics are correlated with local glucose transporter densities in the brain. In 47 brain structures the local rate constants for 3-O-[¹⁴C]methylglucose (3-O-MG) transport, K₁ and k_2, were quantified, and local glucose Glut1 and Glut3 transporter densities were determined by immuno-autoradiographic methods. Statistically significant correlations were found between the rate constants for glucose transport and the transporter densities. The correlations were tighter for Glut1 than for Glut3. Inasmuch as 3-O-MG is transported by the same transporter as glucose, these results indicate that the local densities of glucose transporters determine local glucose transport rates in the brain.

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Acknowledgements

This study was supported by a grant from the Deutsche Forschungsgemeinschaft. The authors thank Dr Lutz Duembgen, Medical University of Luebeck, Luebeck, Germany for statistical support.

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Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain

Abstract

Section snippets

Acknowledgements

J. Biol. Chem.

Brain Res.

Brain Res.

FEBS. Lett.

Brain Res.

Nicotine raises the influx of permeable solutes across the rat blood–brain barrier with little or no capillary recruitment

J. Cereb. Blood Flow Metab.

Direct measurement of the lambda of the lumped constant of the deoxyglucose method in rat brain: determination of lambda and lumped constant from tissue glucose concentration or equilibrium brain/plasma distribution ratio for methylglucose

J. Cereb. Blood Flow Metab.

Local transport kinetics of glucose during acute and chronic nicotine infusion in rat brains

J. Neural Transm.

Glucose transporter localization in brain using light and electron immunocytochemistry

J. Neurosci. Res.