Increased responsiveness of cortical neurons in contrast to thalamic neurons during isoflurane-induced EEG bursts in rats
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Repertoire of mesoscopic cortical activity is not reduced during anesthesia
2016, NeuroscienceCitation Excerpt :Burst-suppression is a distinct condition in which neuronal activity semi-periodically alternates between highly active and profoundly inactive states (Rampil et al., 1991; Steriade et al., 1994; Lukatch et al., 2005; Kenny et al., 2014). Bursting is a hyperexcited state (Hartikainen et al., 1995; Detsch et al., 2002; Hudetz and Imas, 2007; Kroeger and Amzica, 2007) in which the overall (time-averaged) level of spontaneous activity is high. This demonstrates that the number and clustering of CAPs in the visual cortex correlates with the level of neuronal activity rather than with level of consciousness.
Toward Deep Brain Monitoring with Superficial EEG Sensors Plus Neuromodulatory Focused Ultrasound
2016, Ultrasound in Medicine and BiologyGraded defragmentation of cortical neuronal firing during recovery of consciousness in rats
2014, NeuroscienceCitation Excerpt :Spatiotemporal patterns of neuronal activity are strongly influenced by altered states of consciousness such as anesthesia, sleep and wakefulness. Anesthetic agents suppress firing rate (Detsch et al., 2002; Hudetz et al., 2009; Villeneuve et al., 2009), synaptic connectivity (Vizuete et al., 2012), and rhythms of population activity in neuronal networks (Hudetz et al., 2011; Lewis et al., 2012) These changes are thought to impair information processing and consciousness (Alkire et al., 2008; Lee et al., 2009; Brown et al., 2010). A recent study in human patients demonstrated rapid spatial and temporal fragmentation of neuronal activity during propofol-induced unconsciousness (Lewis et al., 2012).
Effects of isoflurane upon minimum alveolar concentration and cerebral cortex depression in pigs and goats: An interspecies comparison
2011, Veterinary JournalCitation Excerpt :This again strengthens the view that iBST indicates a similar level of cerebral function. In isoflurane anaesthetised rats during periods of cortical silence, sensory input from the thalamus to the cortex is inhibited (Detsch et al., 2002; Vahle-Hinz et al., 2007). This suggests that, in the periods of isoelectricity during burst suppression, cerebral function is altered.
The effects of EEG suppression and anesthetics on stimulus thresholds in functional cortical motor mapping
2010, Clinical NeurophysiologyCitation Excerpt :Whereas most authors have attributed them to the interactions within thalamocortical networks, others have demonstrated that sensory cortex and thalamus may be disconnected during burst suppression induced by volatile agents (Detsch et al., 2002). While the discharge rate in the thalamic neurons did not differ during EEG bursts or isoelectric periods, the neurons in the primary somatosensory cortex had a significantly higher amplitude response during bursts than during “flats”, suggesting that the profound suppression of the sensory information is suspended during EEG bursts (Detsch et al., 2002). Studies on rodents suggest that the burst suppression pattern is a combination of both excitatory and inhibitory mechanisms (Lukatch et al., 2005).