Learning-induced multiple synapse formation in rat cerebellar cortex
Section snippets
Acknowledgements
We thank the Beckman Optical Visualization Facility, James Bower, Mark Nelson, Kristen Harris and David Clayton for comments, Ruth Napper for advice on synapse quantification, and Karl Haglund, Rodney Swain, Kim Armstrong and Theresa Jones for assistance. This work was supported by AG 10154, NSF BNS 88 21219 and NSERC.
References (42)
- et al.
Motor-skill learning: changes in synaptic organization of the rat cerebellar cortex
Neurobiol. Learn. Mem.
(1996) An instruction-selection theory of learning in the cerebellar cortex
Brain Res.
(1977)- et al.
Purkinje cell activity during motor learning
Brain Res.
(1977) - et al.
Changes in rabbit cerebellar cortical and interpositus nucleus activity during acquisition, extinction, and backward classical eyelid conditioning
Neurobiol. Learn. Mem.
(1996) Long-term depression as a memory process in the cerebellum
Neurosci. Res.
(1986)- et al.
Induction of multiple synapses by experience in the visual cortex of adult rats
Neurobiol. Learn. Mem.
(1997) - et al.
Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice
Cell
(1995) - et al.
Alterations in rat striatal glutamate synapses following a lesion of the cortico- and/or nigrostriatal pathway
Exp. Neurol.
(2000) - et al.
Quantitative histological analysis of the cerebellar cortex in the cat. I. Number and arrangement in space of the Purkinje cells
Brain Res.
(1971) A theory of cerebellar function
Math. Biosci.
(1971)
Morphological basis of long-term habituation and sensitization in Aplysia
Science
Augmentation of cerebellar responses to parallel fiber activation following skilled motor acquisition in rats
Soc. Neurosci. Abstr.
Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats
Proc. Natl. Acad. Sci. USA
Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice
J. Neurosci.
Functional metabolic mapping during forelimb movement in rat. I. Stimulation of motor cortex
J. Neurosci.
Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs
Proc. Natl. Acad. Sci. USA
Subthreshold synaptic Ca2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons
Nature
Effects of monocular visual deprivation on geniculocortical innervation of area 18 in cat
J. Neurosci.
Adaptive filter model of the cerebellum
Biol. Cybern.
Associative learning elicits the formation of multiple-synapse boutons
J. Neurosci.
How the cerebellum could memorize movements
Nature
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