Increase of urocortin-like immunoreactivity in the rat supraoptic nucleus after dehydration but not food deprivation
Section snippets
Acknowledgements
The technical assistance of Miss Rieko Nishi is greatly appreciated. This study was supported by Grants-in-Aid for Scientific Research, no. 07507004, International Scientific Research, no. 07044296 for H.Y. from the Ministry of Education, Science, Sports and Culture, Japan and Special Grant by the Ministry of Labor for `Occupational Health Studies'.
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Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats
2018, Neuroscience ResearchCitation Excerpt :The oxytocin-mRFP1 transgenic rats showed significant increases in mRFP1 fluorescent intensity in the PP, SON and PVN after chronic salt loading (Katoh et al., 2011) and both acute and chronic nociceptive stimuli (Matsuura et al., 2015; Matsuura et al., 2016). Second, we examined whether urocortin-like immunoreactive (urocortin-LI) cells co-exist with mRFP1 in the SON and PVN of aged oxytocin-mRFP1 transgenic rats because we reported previously that the numbers of urocortin-LI cells in the SON and the PVN were significantly increased in aged rats (Hara et al., 2000) as well as salt-loaded and dehydrated rats (Hara et al., 1997a; Hara et al., 1997b). Urocortin was discovered as a member of the corticotropin-releasing factor (CRF) family (Vaughan et al., 1995).
Urocortins: Actions in health and heart failure
2017, Clinica Chimica ActaCitation Excerpt :In the brain, Ucn1 is expressed most prominently in the Edinger–Westphal nucleus and lateral superior olive, but is also present in the hypothalamus, lateral superior olive cerebellum, substantia nigra pars compacta and ventral tegmental area, hippocampus, basal ganglia, medial septum and paraventricular nucleus [12,13]. Ucn1 immunoreactivity in the rat is increased in the supraoptic nucleus by dehydration and salt loading - suggesting an involvement in the regulation of water and salt homeostasis [14,15], and is colocalized with dopamine in the basal ganglia and hypothalamus. Ucn1 has also been verified in multiple peripheral tissues including the heart, adrenal gland (especially the medulla), kidney, lung, spleen, thymus, skeletal muscles, placenta, skin, immune system and the gastrointestinal tract [16].
Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: Ancient CRF paralogs
2007, Frontiers in NeuroendocrinologyCitation Excerpt :Similarly, unlike CRF antisera, peripheral administration of specific Ucn 1 antisera does not modify basal, stress-induced or adrenalectomy-induced ACTH levels [179,278]. Finally, unlike the distribution of CRF, Ucn 1-immunoreactive fibers are scarce in the PVN and the external layer of the median eminence under basal conditions [100,101,158]. It remains possible, however, that the type 2 Ucns modulate HPA-axis activity at the hypothalamic level in paracrine or autocrine fashion.
Effect of starvation on Fos and neuropeptide immunoreactivities in the brain and pituitary gland of Xenopus laevis
2006, General and Comparative EndocrinologyChapter 2.4 The roles of urocortins 1, 2, and 3 in the brain
2005, Techniques in the Behavioral and Neural SciencesCitation Excerpt :The prominent synthesis of urocortin 2 in magno-cellular SON and PVN neurons also is consistent with a possible osmoregulatory role of urocortin 2. Interestingly, salt loading, dehydration, and hypophysectomy increased urocortin in magno-cellular SON and PVN neurons (Hara et al., 1997a,b, 2000), whereas food deprivation decreased urocortin-LI in the SON (Hara et al., 1997b). The antibody’s specificity for urocortin 1 as opposed to urocortin 2 is unknown, but specific increases in magnocellular SON urocortin 1 mRNA expression also have been observed following salt loading (Imaki et al., 2001).