Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene
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Acknowledgements
This work was supported by NIH grants AG 13672 and AG05133. The technical and clerical help of Mr. Michael Carlin and Ms. Jeanette Norbut, respectively are greatly appreciated.
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LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo
2014, NeuroImage: ClinicalCitation Excerpt :LRP-1 binds to ApoE-linked Aβ as well as to Aβ alone (Fuentealba et al., 2010; Jaeger and Pietrzik, 2008) and mediates endocytosis of the LRP-1/ApoE/Aβ-complex or LRP-1/Aβ-complex (Deane et al., 2008; Gylys et al., 2003). An association study found a protective effect of the TT LRP-1 polymorphism against AD only in ApoE ε4 carriers (Kamboh et al., 1998). Since LRP-1 is involved in multiple mechanisms which could have an influence on the pathogenesis of AD and additionally impact Aβ transcytosis, internalization, processing and degradation, we wished to elucidate on how the C667T polymorphism of the LRP-1 gene is associated with cerebral amyloid load in a cohort of 72 AD patients.
Association of polymorphisms in the LRP1 and A2M genes with Alzheimer's disease in the Northern Chinese Han population
2013, Journal of Clinical NeuroscienceCitation Excerpt :For LRP1 C766T, in the APOE ε4 positive subgroups, the frequency of the T allele (p = 0.004) and the T/T genotype (p = 0.027) was lower in the patients with SAD than in the control subjects and the LRP1 C766T T allele may decrease the risk for development of SAD in APOE ε4 carriers in the Chinese Northern Han population. This result is similar to that reported by Kamboh et al.18 and Hatanaka et al.19 Some investigations have shown that the LRP1 C766T polymorphism is related to the severity of the pathological manifestations of senile plaque and neurofibrillary tangles in patients with SAD. For example, Kang et al.20 found that patients with the LRP1 C/C genotype had more neuritic plaques and tangles than those with the T/T or T/C genotypes.
Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease
2006, Neurobiology of AgingCandidate genes for late-onset Alzheimer's disease: Focus on chromosome 12
2006, Mechanisms of Ageing and Development