Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats

doi:10.1016/S0304-3940(99)00922-2

Neuroscience Letters

Volume 278, Issue 3, 14 January 2000, Pages 157-160

https://doi.org/10.1016/S0304-3940(99)00922-2 Get rights and content

Abstract

The endogenous cannabinoids (endocannabinoids) anandamide and 2-arachidonylglycerol increased cell viability in cerebral cortical neuron cultures subjected to 8 h of hypoxia and glucose deprivation. This effect was observed at nanomolar concentrations, was reproduced by a non-hydrolyzable analog of anandamide, and was unaltered by CB1 or CB2 cannabinoid receptor antagonists. Like synthetic cannabinoids, endocannabinoids can protect neurons from hypoxic injury, and may represent endogenous neuroprotective molecules in cerebral ischemia.

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Acknowledgements

This work was supported in part by National Institutes of Health Grant NS35965.

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Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats

Abstract

Section snippets

Acknowledgements

Trends Neurosci.

Brain Res.

J. Neurosci. Methods

(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability

J. Med. Chem.

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

Science

Hippocampal neurotoxicity of Δ9-tetrahydrocannabinol

J. Neurosci.

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

Science

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

Nature